Egashira Nobuaki, Kurauchi Kouji, Iwasaki Katsunori, Mishima Kenichi, Orito Kensuke, Oishi Ryozo, Fujiwara Michihiro
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Phytother Res. 2008 Jan;22(1):49-52. doi: 10.1002/ptr.2258.
The present study investigated the effect of schizandrin, a component of the fruit of Schizandra chinesis Baill (Fructus Schizandrae), on memory impairment in rats. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, markedly impaired spatial memory in an eight-arm radial maze. A higher dose of scopolamine (3 mg/kg, i.p.) also impaired the passive avoidance response. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist. Taken together these findings suggest that schizandrin reverses scopolamine-induced memory impairment, in part, by enhancing cholinergic function, and that schizandrin might be useful for treating memory deficits.
本研究考察了五味子果实中的成分五味子醇对大鼠记忆损伤的影响。东莨菪碱（0.5毫克/千克，腹腔注射），一种非选择性毒蕈碱受体拮抗剂，显著损害了八臂放射状迷宫中的空间记忆。更高剂量的东莨菪碱（3毫克/千克，腹腔注射）也损害了被动回避反应。五味子醇（1和10毫克/千克，口服）显著逆转了东莨菪碱诱导的空间记忆损伤。同样，五味子醇（1毫克/千克，口服）显著逆转了东莨菪碱诱导的被动回避反应损伤。此外，在小鼠中，五味子醇（1和10毫克/千克，口服）增强了毒蕈碱M(1)受体激动剂氧化震颤素诱导的震颤。综合这些发现表明，五味子醇部分通过增强胆碱能功能来逆转东莨菪碱诱导的记忆损伤，并且五味子醇可能对治疗记忆缺陷有用。
