Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, No. 2, Zheshan West Road, Jinghu District, Wuhu, 241000, China.
Wannan Medical College, No.22, Wenchang West Road, Yijiang District, Wuhu, 241000, China.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Feb;397(2):783-794. doi: 10.1007/s00210-023-02687-z. Epub 2023 Sep 1.
Schisandrin stands as one of the primary active compounds within the widely used traditional medicinal plant Schisandra chinensis (Turcz.) Baill. This compound exhibits sedative, hypnotic, anti-aging, antioxidant, and immunomodulatory properties, showcasing its effectiveness across various liver diseases while maintaining a favorable safety profile. However, the bioavailability of schisandrin is largely affected by hepatic and intestinal first-pass metabolism, which limits the clinical efficacy of schisandrin. In this paper, we review the various pharmacological effects and related mechanisms of schisandrin, in order to provide reference for subsequent drug research and promote its medicinal value.
五味子醇甲是广泛应用的传统药用植物五味子（Turcz.）Baill.中的主要活性化合物之一。该化合物具有镇静、催眠、抗衰老、抗氧化和免疫调节作用，在各种肝病中表现出有效性，同时保持良好的安全性。然而，五味子醇甲的生物利用度在很大程度上受到肝肠首过代谢的影响，限制了五味子醇甲的临床疗效。本文综述了五味子醇甲的各种药理作用及相关机制，为后续药物研究提供参考，促进其药用价值。
