来自白 Lippia 的多酚和环烯醚萜的抗氧化和神经镇静特性。

Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba.

作者信息

Hennebelle Thierry, Sahpaz Sevser, Gressier Bernard, Joseph Henry, Bailleul François

机构信息

Laboratoire de Pharmacognosie, EA 1043, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2, Lille, France.

出版信息

Phytother Res. 2008 Feb;22(2):256-8. doi: 10.1002/ptr.2266.

DOI:10.1002/ptr.2266

PMID:17705148

Abstract

The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABA(A) receptors. The most active compound was luteolin-7-diglucuronide, with half maximal inhibitory concentrations (IC(50)) of 101 and 40 microm, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin-7-diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical-anion in cell-free (hypoxanthine-xanthine oxidase) and cellular (PMA-stimulated neutrophil granulocytes) systems.

摘要

对从白香蜂草柠檬醛化学型中分离出的一些主要化合物的神经镇静和抗氧化特性进行了研究。在两个中枢神经系统抑制靶点上进行了结合试验：苯二氮䓬受体和GABA(A)受体。活性最强的化合物是木犀草素-7-二葡萄糖醛酸苷，其半数最大抑制浓度（IC(50)）分别为101和40微摩尔。测试了从白香蜂草中分离出的15种化合物对DPPH的自由基清除能力。还测试了四种主要化合物（毛蕊花糖苷、柳穿鱼苷E、木犀草素-7-二葡萄糖醛酸苷和theveside）在无细胞（次黄嘌呤-黄嘌呤氧化酶）和细胞（佛波酯刺激的中性粒细胞）系统中对超氧阴离子自由基的抗氧化活性。