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三种牛至属植物（ 、 和 ）多酚提取物的细胞毒性：对两种类型乳腺癌细胞系（MDA-MB-231 和 MCF-7）的抗增殖潜力。

Cytotoxic Activity of Polyphenol Extracts from Three Oregano Species: , and and Antiproliferative Potential of against Two Types of Breast Cancer Cell Lines (MDA-MB-231 and MCF-7).

机构信息

Centro de Investigación en Alimentación y Desarrollo, AC. Carretera a Eldorado Km 5.5, Col. Campo el Diez, Culiacán CP 80110, SI, Mexico.

Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Calzada de Las Américas Norte 2771, Col. Burócrata, Culiacán CP 80030, SI, Mexico.

出版信息

Molecules. 2022 Aug 17;27(16):5240. doi: 10.3390/molecules27165240.

DOI:10.3390/molecules27165240
PMID:36014479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9415836/
Abstract

Oregano infusions have traditionally been used to treat some diseases related to inflammation and cancer; also, some species have shown antiproliferative activity on cancer cell lines, for example, colon and liver, and this has been attributed to its phytochemical profile, mainly its phenolic compounds. This study aimed to evaluate the cytotoxicity and antiproliferative potential of the polyphenols-rich extracts (PRE) of the oregano species , and on breast cancer cell lines. The PRE of the three oregano species were obtained from dried leaves. The extract was characterized by determining antioxidant activity, total phenols content, and identifying the profile of phenolic acids and flavonoids by chromatography UPLC-MS/MS. Furthermore, the cytotoxicity of the extracts was evaluated in vitro on a non-cancer cell line of fibroblast NIH3T3 and the antiproliferative potential on the breast cancer cell lines MDA-MB-231 and MCF-7. showed the highest antioxidant capacity and significantly inhibited the proliferation of MCF-7 and MDA-MB-231 cells at non-cytotoxic concentrations in normal cells, with a similar effect to that cisplatin in MDA-MB-231 cells. Therefore, the polyphenol-rich extract from showed the greatest potential to guide future research on the antiproliferative mechanism of action.

摘要

牛至属植物的浸剂传统上被用于治疗一些与炎症和癌症相关的疾病；此外，一些物种对癌细胞系显示出抗增殖活性，例如结肠和肝脏，这归因于其植物化学特征，主要是其酚类化合物。本研究旨在评估富含多酚的牛至属植物提取物 (PRE) 的细胞毒性和抗增殖潜力，以及对乳腺癌细胞系的作用。三种牛至属植物的 PRE 是从干燥的叶子中获得的。提取物通过测定抗氧化活性、总酚含量以及通过 UPLC-MS/MS 色谱法鉴定酚酸和类黄酮的特征来表征。此外，还在非癌细胞系 NIH3T3 上评估了提取物的体外细胞毒性，并在正常细胞的非细胞毒性浓度下评估了对乳腺癌细胞系 MDA-MB-231 和 MCF-7 的抗增殖潜力。在 MDA-MB-231 细胞中，与顺铂具有相似的作用，对 MCF-7 和 MDA-MB-231 细胞的增殖具有最高的抗氧化能力，并显著抑制增殖，而在正常细胞中浓度没有细胞毒性。因此，富含多酚的 提取物显示出最大的潜力来指导对其抗增殖作用机制的未来研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/e18ecb577124/molecules-27-05240-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/7d904c15ff8f/molecules-27-05240-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/bbfbbb6da03d/molecules-27-05240-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/cf11b10139dc/molecules-27-05240-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/c18ae9d4208d/molecules-27-05240-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/9963e5ad88e7/molecules-27-05240-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/e18ecb577124/molecules-27-05240-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/7d904c15ff8f/molecules-27-05240-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/bbfbbb6da03d/molecules-27-05240-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/cf11b10139dc/molecules-27-05240-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/c18ae9d4208d/molecules-27-05240-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/9963e5ad88e7/molecules-27-05240-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41f/9415836/e18ecb577124/molecules-27-05240-g006.jpg

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