病毒源性肝细胞癌患者血液和组织中的谷胱甘肽状态
Glutathione status in the blood and tissues of patients with virus-originated hepatocellular carcinoma.
作者信息
Lee King-Teh, Tsai Shih-Meng, Wang Shen-Nien, Lin Shu-Kai, Wu Szu-Hwa, Chuang Shih-Chung, Wu Szu-Hsien, Ma Hsu, Tsai Li-Yu
机构信息
Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
出版信息
Clin Biochem. 2007 Oct;40(15):1157-62. doi: 10.1016/j.clinbiochem.2007.06.012. Epub 2007 Jul 5.
OBJECTIVES
Glutathione status can be regarded as the redox status for many diseases. This study was performed to investigate the glutathione status in virus-originated hepatocellular carcinoma (HCC).
DESIGN AND METHODS
The blood and tissue samples were obtained from 24 patients. Blood samples were also obtained from 137 controls for comparison.
RESULTS
The GSH level and the ratios of GSH/GSSG and GSH/total glutathione of the blood samples from the patients were significantly lower than those of the controls, while the GSSG values were significantly higher. Meanwhile, levels of GSH and total glutathione, as well as the ratios of GSH/GSSH and GSH/total glutathione, were significantly decreased, whereas GSSG levels were significantly higher, in the HCC tissues than those of the adjacent cancer-free tissues.
CONCLUSIONS
Glutathione status in the HCC suggested that the antioxidant system is severely impaired, supporting a consistent role of the free radical cytotoxicity in the pathophysiology of the disease.
目的
谷胱甘肽状态可被视为多种疾病的氧化还原状态。本研究旨在调查病毒源性肝细胞癌（HCC）中的谷胱甘肽状态。
设计与方法
从24例患者获取血液和组织样本。还从137名对照者获取血液样本以作比较。
结果
患者血液样本中的谷胱甘肽（GSH）水平、GSH/氧化型谷胱甘肽（GSSG）比值以及GSH/总谷胱甘肽比值显著低于对照组，而GSSG值显著更高。同时，HCC组织中的GSH和总谷胱甘肽水平以及GSH/GSSH和GSH/总谷胱甘肽比值显著降低，而GSSG水平显著高于相邻的无癌组织。
结论
HCC中的谷胱甘肽状态表明抗氧化系统严重受损，支持自由基细胞毒性在该疾病病理生理学中的持续作用。
Zotero 插件