Paydas Semra, Ergin Melek, Erdogan Seyda, Seydaoglu Gulsah, Yavuz Sinan, Disel Umut
Department of Oncology, Cukurova University Faculty of Medicine, Turkey.
Leuk Res. 2008 Feb;32(2):243-50. doi: 10.1016/j.leukres.2007.06.024. Epub 2007 Aug 13.
Survivin (S) is a member of inhibitor of apoptosis family (IAP) and is expressed in the majority of malignant tumors but undetectable in normal differentiated adult tissues. S is an encouraging target for cancer therapy. TSP-1 is a multifunctional protein regulating cell growth, motility and apoptosis in both physiological and pathological conditions. The role of TSP-1 in cancer progression remains controversial. We aimed to determine the pathogenetic and prognostic role of TSP-1 and S in non-Hodgkin's lymphomas (NHL). S and TSP-1 expressions were looked for in 177 cases with NHL. S was found to be positive in 94 of the cases (53%). TSP-1 was found to be positive in 31 of the cases (17.5%). There was a strong association between S and TSP-1 and also aggressive histology with S and TSP-1. The overall survival (OS) times were longer in cases without S expression than cases with S expression (p=0.0514). Although the OS was shorter in TSP-1 expressing cases as compared with TSP-1 (-) cases, difference was not significant (p=0.2428). In conclusion, S and TSP-1 expressions were detected in 53 and 17.5% of the cases with NHL, and are associated with aggressive histology and shorter OS.
生存素（S）是凋亡抑制蛋白家族（IAP）的成员之一，在大多数恶性肿瘤中表达，但在正常分化的成人组织中无法检测到。S是癌症治疗中一个令人鼓舞的靶点。血小板反应蛋白-1（TSP-1）是一种多功能蛋白，在生理和病理条件下调节细胞生长、运动和凋亡。TSP-1在癌症进展中的作用仍存在争议。我们旨在确定TSP-1和S在非霍奇金淋巴瘤（NHL）中的致病和预后作用。在177例NHL病例中检测S和TSP-1的表达。发现94例（53%）病例中S呈阳性。发现31例（17.5%）病例中TSP-1呈阳性。S和TSP-1之间以及S和TSP-1与侵袭性组织学之间存在密切关联。无S表达病例的总生存（OS）时间长于有S表达病例（p = 0.0514）。尽管与TSP-1（-）病例相比，TSP-1表达病例的OS较短，但差异无统计学意义（p = 0.2428）。总之，在53%的NHL病例和17.5%的病例中检测到S和TSP-1表达，且它们与侵袭性组织学和较短的OS相关。
