Borue Xenia, Chen John, Condron Barry G
University of Virginia Medical Scientist Training Program and University of Virginia Neuroscience Graduate Program, Charlottesville, VA 22904, USA.
Int J Dev Neurosci. 2007 Oct;25(6):341-7. doi: 10.1016/j.ijdevneu.2007.06.003. Epub 2007 Jul 7.
Selective serotonin reuptake inhibitors (SSRIs) are utilized in the treatment of depression in pregnant and lactating women. SSRIs may be passed to the fetus through the placenta and the neonate through breastfeeding, potentially exposing them to SSRIs during peri- and postnatal development. However, the long-term effects of this SSRI exposure are still largely unknown. The simplicity and genetic amenability of model organisms provides a critical experimental advantage compared to studies with humans. This review will assess the current research done in animals that sheds light on the role of serotonin during development and the possible effects of SSRIs. Experimental studies in rodents show that administration of SSRIs during a key developmental window creates changes in brain circuitry and maladaptive behaviors that persist into adulthood. Similar changes result from the inhibition of the serotonin transporter or monoamine oxidase, implicating these two regulators of serotonin signaling in developmental changes. Understanding the role of serotonin in brain development is critical to identifying the possible effects of SSRI exposure.
选择性5-羟色胺再摄取抑制剂（SSRIs）被用于治疗怀孕和哺乳期妇女的抑郁症。SSRIs可能会通过胎盘传递给胎儿，并通过母乳喂养传递给新生儿，从而使他们在围产期和产后发育过程中接触到SSRIs。然而，这种SSRIs暴露的长期影响在很大程度上仍然未知。与人体研究相比，模式生物的简单性和遗传易操作性提供了关键的实验优势。本综述将评估目前在动物身上所做的研究，这些研究揭示了5-羟色胺在发育过程中的作用以及SSRIs可能产生的影响。啮齿动物的实验研究表明，在关键发育窗口期间给予SSRIs会导致大脑回路和适应不良行为的改变，这些改变会持续到成年期。5-羟色胺转运体或单胺氧化酶的抑制也会导致类似的变化，这表明这两种5-羟色胺信号调节因子与发育变化有关。了解5-羟色胺在大脑发育中的作用对于确定SSRIs暴露可能产生的影响至关重要。
