Nelson Caleb P
Department of Urology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02155, USA.
J Urol. 2007 Oct;178(4 Pt 1):1463-8; discussion 1468. doi: 10.1016/j.juro.2007.05.167. Epub 2007 Aug 16.
We used a national pediatric database to investigate the association of patient race with timing of surgery for ureteropelvic junction obstruction.
The Kids' Inpatient Database is a national database containing 5.5 million pediatric hospitalizations (patients younger than 21 years) during the years 2000 to 2003. We used International Classification of Disease-9 codes to identify patients undergoing pyeloplasty, and investigated patient and hospital factors associated with timing of surgery using multivariable linear and mixed models.
A total of 2,989 patients underwent pyeloplasty. Mean patient age was 72.3 months (median 36). Of the patients 69.3% were male and 66.0% were white. White patients were significantly older than nonwhite patients (82.3 vs 52.8 months, p <0.0001). The proportion of patients undergoing surgery during the first 12 months of life also varied by race (31.3% among white vs 46.9% among nonwhite patients, p <0.0001). Other factors associated with younger age included male gender (p = 0.0002), hospital volume and teaching status (p <0.0001), and Medicaid insurance (p <0.0001). Socioeconomic status at the zip code level was not associated with timing of surgery. Using a multivariable mixed model to adjust for all variables, including random effects of individual hospitals, nonwhite race was still associated with earlier surgery (p = <0.0001).
This study confirms that nonwhite patients undergo pyeloplasty an average of more than 2.5 years earlier than white patients (even after adjusting for insurance status and other factors). Future research should elucidate the clinical factors that influence surgical decision making in ureteropelvic junction obstruction, including socioeconomic and cultural factors among families and providers, as well as possible biological differences between racial groups in the natural history of ureteropelvic junction obstruction.
我们利用一个全国性儿科数据库,研究患者种族与肾盂输尿管连接处梗阻手术时机之间的关联。
儿童住院患者数据库是一个全国性数据库,包含2000年至2003年期间550万例儿科住院病例(年龄小于21岁的患者)。我们使用国际疾病分类第九版编码来识别接受肾盂成形术的患者,并使用多变量线性模型和混合模型研究与手术时机相关的患者及医院因素。
共有2989例患者接受了肾盂成形术。患者平均年龄为72.3个月(中位数为36个月)。患者中69.3%为男性,66.0%为白人。白人患者明显比非白人患者年龄大(82.3个月对52.8个月,p<0.0001)。出生后前12个月内接受手术的患者比例也因种族而异(白人患者中为31.3%,非白人患者中为46.9%,p<0.0001)。与年龄较小相关的其他因素包括男性(p = 0.0002)、医院手术量和教学状况(p<0.0001)以及医疗补助保险(p<0.0001)。邮政编码层面的社会经济地位与手术时机无关。使用多变量混合模型对所有变量进行调整,包括各医院的随机效应,非白人种族仍与更早进行手术相关(p = <0.0001)。
本研究证实,非白人患者接受肾盂成形术的时间平均比白人患者早2.5年以上(即使在调整保险状况和其他因素之后)。未来的研究应阐明影响肾盂输尿管连接处梗阻手术决策的临床因素,包括家庭和医疗服务提供者中的社会经济和文化因素,以及种族群体在肾盂输尿管连接处梗阻自然病程中的可能生物学差异。