Chen D, Studer A, Lütolf O, Schaffner T, Mahler F
Angiologische Abteilung, Medizinischen Universitätsklinik, Inselspital, Universität Bern.
Klin Wochenschr. 1991 Nov 15;69(18):836-41. doi: 10.1007/BF01649455.
Quantitative finger nailfold capillary microscopy was performed in 25 patients with type I diabetes and in 27 healthy control subjects. In the last consecutive 6 patients and 7 controls of these populations, finger nailfold biopsies were taken. Measurements of loop width as an in vivo parameter for deformities of the capillary loops showed significantly higher values in diabetic patients than in controls. Histopathological examination showed markedly and significantly increased deposition of collagen in nailfold dermal papillae of the diabetic patients. The deposition of collagen was positively correlated with the number of capillary endothelial cells in the nailfold dermal papillae and with the size of the papillae in diabetic patients. It is concluded that, in addition to deformity of nailfold capillaries, collagen deposition may also be a sign of metabolic disturbance and perhaps of proliferation of capillary endothelial cells in diabetic microangiopathy.
对25例I型糖尿病患者和27名健康对照者进行了定量甲襞毛细血管显微镜检查。在这些人群中最后连续的6例患者和7名对照者中，进行了甲襞活检。作为毛细血管袢畸形的体内参数，袢宽度的测量显示糖尿病患者的值显著高于对照组。组织病理学检查显示，糖尿病患者甲襞真皮乳头中胶原蛋白的沉积明显且显著增加。糖尿病患者中胶原蛋白的沉积与甲襞真皮乳头中毛细血管内皮细胞的数量以及乳头大小呈正相关。得出的结论是，除了甲襞毛细血管畸形外，胶原蛋白沉积也可能是代谢紊乱的标志，也许是糖尿病微血管病变中毛细血管内皮细胞增殖的标志。
