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[莱昂市辖区内恶性皮肤黑色素瘤的流行病学与临床研究]

[An epidemiological and clinical study of malignant cutaneous melanoma in the catchment area of León].

作者信息

Rubio Ruiz J, Giménez García R, Naveiro Rilo J, Salcedo Joven V, Díez Estrada M, Mayoral Gómez A

机构信息

Unidad Docente de Medicina Familiar y Comunitaria, León.

出版信息

Med Clin (Barc). 1991 Nov 23;97(18):693-6.

PMID:1770819
Abstract

BACKGROUND

During the last decade the incidence of cutaneous malignant melanoma (CMM) has increased in different geographic areas around the world. The aim of this study is to know the incidence and clinical characteristics of CMM in the area of Leon between 1980-1989.

METHODS

One hundred nineteen cases corresponding to the total CMM cases diagnosed over the aforementioned period were reviewed. Clinical characteristics were studied and the annual and five-year incidence were calculated. Results were compared between two five year period (1980-1984 and 1985-1989).

RESULTS

The mean annual incidence rose from 1.9 in the first five year period to 4.4 cases per one hundred thousand cases per year in the second period (p less than 0.01). Furthermore, in this period a diminution was observed in the diagnosis of CMM with an elevated Clark level (III-V), with an increase of the lowest levels (p less than 0.05). There was a high predominance of women (76%) which increased in the second five year period (p less than 0.05). The mean age was 61.7 years which was higher than that reported by other authors with the most frequent sites being: head-neck (40%) and trunk (25%) The predominant histology was melanoma of superficial spread (46%). These variables did not vary significantly throughout the period studied.

摘要

背景

在过去十年间,皮肤恶性黑色素瘤(CMM)的发病率在世界不同地理区域均有所上升。本研究旨在了解1980 - 1989年期间莱昂地区CMM的发病率及临床特征。

方法

回顾了上述时期诊断出的119例CMM病例。研究临床特征并计算年发病率和五年发病率。对两个五年期(1980 - 1984年和1985 - 1989年)的结果进行比较。

结果

年平均发病率从第一个五年期的1.9例上升至第二个五年期的每年每十万例4.4例(p < 0.01)。此外,在此期间,观察到Clark分级较高(III - V级)的CMM诊断数量减少,而最低分级的数量增加(p < 0.05)。女性占比很高(76%),且在第二个五年期有所增加(p < 0.05)。平均年龄为61.7岁,高于其他作者报告的年龄,最常见的发病部位为:头颈(40%)和躯干(25%)。主要组织学类型为浅表扩散型黑色素瘤(46%)。在整个研究期间,这些变量没有显著变化。

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