Heianna Joichi, Miyauchi Takaharu, Suzuki Toshio, Ishida Hideaki, Hashimoto Manabu, Watarai Jiro
Department of Radiology, Akita Redcross Hospital, Akita, Japan.
Hepatogastroenterology. 2007 Jul-Aug;54(77):1560-2.
Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. Some reports have described cases of spontaneous regression of HCC, but there have been few cases with spontaneous regression of only metastatic lesions from HCC. We report a case of a 70-year-old woman with multiple lung metastases from HCC that regressed spontaneously following regression of HCC after transcatheter arterial embolization (TAE). To our knowledge, this is the first reported case that multiple lung metastases regressed spontaneously following TAE for HCC. Numerous mechanisms for spontaneous regression of HCC have been suggested such as subintimal damage, blood transfusion, alcohol withdrawal, infection, hemorrhagic shock, hepatic artery occlusion and herbal medicine. Our case, however, had no connection with any such symptom and medication. Our case suggests that the mechanisms leading to spontaneous regression in remote organs may be associated with activation of host immune response involving cytokines.
肝细胞癌（HCC）的自发消退是一种罕见现象。一些报告描述了HCC自发消退的病例，但仅有HCC转移灶自发消退的病例很少。我们报告一例70岁女性，患有HCC的多发肺转移，在经导管动脉栓塞术（TAE）后HCC消退，随后转移灶也自发消退。据我们所知，这是首例报道的TAE治疗HCC后多发肺转移灶自发消退的病例。关于HCC自发消退的机制有多种推测，如内膜下损伤、输血、戒酒、感染、失血性休克、肝动脉闭塞和草药等。然而，我们的病例与任何此类症状和药物均无关联。我们的病例提示，导致远处器官自发消退的机制可能与涉及细胞因子的宿主免疫反应激活有关。
