Cresteil T, Counis R, Raulin J
Biochimie. 1975 Nov-Dec;57(11-12):1371-6.
An adenylate cyclase activity (AC) was found in guinea pig brown adipose tissue (BAT), since the tissue's apparition. This enzymatic activity increased during the development and showed high values at the end of gestation. An increase of AC units per cell was observed, in addition to the cell multiplication. A norepinephrine stimulation of AC activity was observed at the end of gestation : this regulating action disappeared in the first days of extrauterine life. Neither glucagon nor ACTH had any regulating role upon AC activity during fetal and newborn life. The basal lipolytic activity which was observed in BAT of fetuses (61rst day) and neonate dramatically around the 15th day. A potent lipolysis activation by norepinephrine was observed, but only after birth. The correlation observed between these enzymatic activities in presence of norepinephrine seems to indicate that the AC/lipase system was involved in the neonatal thermogenesis of guinea pigs.
自豚鼠褐色脂肪组织（BAT）出现以来，就发现了一种腺苷酸环化酶活性（AC）。这种酶活性在发育过程中增加，并在妊娠末期呈现高值。除了细胞增殖外，还观察到每个细胞的AC单位增加。在妊娠末期观察到去甲肾上腺素对AC活性的刺激作用：这种调节作用在出生后的头几天消失。在胎儿期和新生儿期，胰高血糖素和促肾上腺皮质激素对AC活性均无调节作用。在胎儿（第61天）和新生儿的BAT中观察到基础脂解活性在第15天左右急剧变化。观察到去甲肾上腺素能有效激活脂解作用，但仅在出生后。在去甲肾上腺素存在的情况下观察到的这些酶活性之间的相关性似乎表明，AC/脂肪酶系统参与了豚鼠的新生儿产热过程。
