因巨大桥本纤维性甲状腺炎行甲状腺全切除术后，持续发热迅速消退。

Sustained fever resolved promptly after total thyroidectomy due to huge Hashimoto's fibrous thyroiditis.

作者信息

Kubota Sumihisa, Matsuzuka Fumio, Ohye Hidemi, Nishihara Eijun, Kudo Takumi, Ito Mitsuru, Arishima Takeshi, Fukata Shuji, Hirokawa Mitsuyoshi, Amino Nobuyuki, Miyauchi Akira

机构信息

Kuma Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe, 650-0011, Japan.

出版信息

Endocrine. 2007 Feb;31(1):88-91. doi: 10.1007/s12020-007-0013-z.

DOI:10.1007/s12020-007-0013-z

PMID:17709903

Abstract

We encountered a 55-year-old female patient with Hashimoto's thyroiditis who showed persistent fever, and could not find any source of fever other than the large nontender goiter. Her fever continued with positive CRP for 6 months. Although we did not assume that the inflammation was related to Hashimoto's thyroiditis, total thyroidectomy was performed for cosmetic reasons; however, fever was resolved immediately after thyroidectomy. Pathological diagnosis was Hashimoto's chronic thyroiditis. Immunohistochemical staining showed that the follicular cells were positive for IL-1alpha, IL-1beta, and TNF-alpha. We believed that fever was induced by inflammatory cytokines produced in thyroid. The case indicated that Hashimoto's thyroiditis with nontender goiter could cause idiopathic fever.

摘要

我们遇到一位55岁患有桥本甲状腺炎的女性患者，她持续发热，除了一个无压痛的大甲状腺肿外找不到任何发热源。她的发热持续，CRP呈阳性达6个月。尽管我们没有认为炎症与桥本甲状腺炎有关，但出于美容原因进行了全甲状腺切除术；然而，甲状腺切除术后发热立即消退。病理诊断为桥本慢性甲状腺炎。免疫组化染色显示滤泡细胞IL-1α、IL-1β和TNF-α呈阳性。我们认为发热是由甲状腺产生的炎性细胞因子所致。该病例表明，伴有无压痛甲状腺肿的桥本甲状腺炎可引起不明原因发热。