Ishihara T, Mori T, Waseda N, Ikekubo K, Kurahachi H, Imura H
Second Division of Internal Medicine, Kyoto University School of Medicine, Japan.
Endocrinol Jpn. 1988 Apr;35(2):231-6. doi: 10.1507/endocrj1954.35.231.
Histocompatibility lymphocytic antigen (HLA) typing was performed in 6 patients with acute exacerbation of Hashimoto's thyroiditis whose diagnoses were established on the basis of typical histological findings, and was compared with those of 12 with subacute thyroiditis, 33 with general Hashimoto's thyroiditis and also with a control group. There was a high incidence of BW35 in patients with subacute thyroiditis, although it was only seen in 1 of 6 patients with acute exacerbation. The difference was statistically significant (p less than 0.01). Four of 6 patients with acute exacerbation had DR2 and none of them had DR4, which was the reverse of the findings for Hashimoto's thyroiditis patients in general, and the difference in the incidence of DR2 was significant (p less than 0.001). None of the HLA types in patients with acute exacerbation was significantly different from those of the control group. In conclusion, HLA typing in patients with acute exacerbation was different from those of subacute thyroiditis and general Hashimoto's thyroiditis. Acute exacerbation was considered to involve quite a limited and rather unique population among patients with Hashimoto's thyroiditis.
对6例诊断基于典型组织学表现的桥本甲状腺炎急性加重期患者进行了组织相容性淋巴细胞抗原（HLA）分型，并与12例亚急性甲状腺炎患者、33例普通桥本甲状腺炎患者以及一个对照组进行了比较。亚急性甲状腺炎患者中BW35的发生率较高，尽管在6例急性加重期患者中仅1例出现。差异具有统计学意义（p小于0.01）。6例急性加重期患者中有4例具有DR2，且无一例具有DR4，这与普通桥本甲状腺炎患者的结果相反，DR2发生率的差异具有显著性（p小于0.001）。急性加重期患者的HLA类型与对照组相比均无显著差异。总之，急性加重期患者的HLA分型与亚急性甲状腺炎和普通桥本甲状腺炎患者不同。急性加重期被认为仅涉及桥本甲状腺炎患者中相当有限且独特的一部分人群。
