Kapural Leonardo, Mekhail Nagy, Bena James, McLain Robert, Tetzlaff John, Kapural Miranda, Mekhail Mena, Polk Samuel
Department of Pain Management, Cleveland Clinic, Cleveland, OH 44195, USA.
Clin J Pain. 2007 Sep;23(7):571-5. doi: 10.1097/AJP.0b013e3180e00c34.
Purpose of this study is to examine the relationship between the magnetic resonance imaging (MRI) findings, pain scores, and opiates use in patients with lumbar spinal stenosis (LSS) undergoing lumbar epidural steroid (LES) injections by retrospective review of 719 patients' electronic medical records.
Reviewed were Visual Analog Scale (VAS) pain scores and opioid use before and 8 to 12 weeks after series of LES injections. The stenosis pain index (SPI) was produced by adding an assigned numerical value of severity (1=mild, 2=moderate, 3=severe) to the number of lumbar vertebral levels affected by LSS on MRI (lateral or central).
The average age of patients was 68.4 years. There was no relationship between the pretreatment age, sex, or number of vertebral levels affected on MRI with pretreatment VAS pain scores or opioid use. The degree of LSS present on MRI, categorized as a mild, moderate, or severe, correlated clearly with initial VAS pain scores (P=0.017). The improvement in VAS pain scores after LES injections correlated well with number of levels affected (P=0.003) and the severity of stenosis (P=0.12). Positive correlation was observed between change in VAS pain score 8 to 12 weeks after the series of LES injections and the SPI (P=0.001). There were no differences found in opioid use.
The improvement in VAS pain scores after LES injections correlated well with the changes in the SPI except in those patients classified on MRI as severe LSS and more than 3 lumbar levels affected. That patient group is unlikely to benefit from LES injections.
本研究的目的是通过回顾719例患者的电子病历,探讨接受腰椎硬膜外类固醇(LES)注射的腰椎管狭窄症(LSS)患者的磁共振成像(MRI)结果、疼痛评分与阿片类药物使用之间的关系。
回顾了一系列LES注射前以及注射后8至12周的视觉模拟量表(VAS)疼痛评分和阿片类药物使用情况。狭窄疼痛指数(SPI)是通过将严重程度的指定数值(1 = 轻度,2 = 中度,3 = 重度)与MRI上受LSS影响的腰椎椎体节段数(外侧或中央)相加得出的。
患者的平均年龄为68.4岁。MRI上的预处理年龄、性别或受影响的椎体节段数与预处理VAS疼痛评分或阿片类药物使用之间没有关系。MRI上存在的LSS程度,分为轻度、中度或重度,与初始VAS疼痛评分明显相关(P = 0.017)。LES注射后VAS疼痛评分的改善与受影响的节段数(P = 0.003)和狭窄严重程度(P = 0.12)密切相关。在一系列LES注射后8至12周VAS疼痛评分的变化与SPI之间观察到正相关(P = 0.001)。在阿片类药物使用方面未发现差异。
LES注射后VAS疼痛评分的改善与SPI的变化密切相关,但MRI分类为严重LSS且超过3个腰椎节段受影响的患者除外。该患者群体不太可能从LES注射中获益。