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经皮椎间孔入路 versus 经皮硬膜外注射类固醇治疗有症状的腰椎管狭窄症。

Interlaminar versus transforaminal epidural steroid injections for the treatment of symptomatic lumbar spinal stenosis.

机构信息

Department of Rehabilitation Medicine, Emory University, Atlanta, Georgia 30322, USA.

出版信息

Pain Med. 2010 Oct;11(10):1511-5. doi: 10.1111/j.1526-4637.2010.00932.x. Epub 2010 Aug 23.

Abstract

BACKGROUND

Lumbar spinal stenosis is a common condition that causes axial low back pain, radicular pain, and neurogenic claudication. Epidural steroid injections are commonly used for the treatment of radicular symptoms and neurogenic claudication associated with symptomatic lumbar spinal stenosis. No prior study has evaluated whether transforaminal or interlaminar epidural steroid injections produce better clinical outcomes.

DESIGN

Retrospective case control study.

METHODS

For each technique, 19 patients were retrospectively identified who received their first fluoroscopically guided epidural steroid injection for radicular and neurogenic claudication symptoms caused by lumbar spinal stenosis over a 12-month interval. All patients had corresponding MRI findings and had failed previous non-invasive therapies. Outcomes included the visual analog scale (VAS, 0-10 scale) immediately before the injection, immediately after the injection, and upon follow up at 4-6 weeks. Surgery rates and number of repeat injections over a 3 year period were also analyzed. The patient groups were matched for age and level of stenosis on MRI.

RESULTS

There was no statistically significant difference between the two groups in pre injection to follow up VAS scores (P=0.919). The difference between number of repeat injections between the interlaminar and transforaminal groups was not statistically significant (0.91-mean 2.47 and 2.58, respectively). Both the interlaminar and transforaminal groups experienced statistically significant improvement in VAS scores from before the injection to after the injection, and on follow up. Low numbers underwent surgery (11% in the interlaminar group vs 15% in the transforaminal group, not significant, P=0.63).

CONCLUSIONS

In the current study, neither transforaminal nor interlaminar steroid injections resulted in superior short term pain improvement or fewer long term surgical interventions or repeat injections when compared with each other.

摘要

背景

腰椎管狭窄症是一种常见的疾病,会导致轴向腰痛、神经根痛和神经性跛行。硬膜外类固醇注射常用于治疗与症状性腰椎管狭窄相关的神经根症状和神经性跛行。以前没有研究评估经椎间孔或椎板间硬膜外类固醇注射是否能产生更好的临床结果。

设计

回顾性病例对照研究。

方法

对于每种技术,在 12 个月的时间间隔内,回顾性地确定了 19 名患者,他们因腰椎管狭窄症引起的神经根和神经性跛行症状,接受了第一次荧光引导下硬膜外类固醇注射。所有患者均有相应的 MRI 发现,并已接受过先前的非侵入性治疗。结果包括注射前、注射后即刻和 4-6 周随访时的视觉模拟评分(VAS,0-10 分)。还分析了 3 年内手术率和重复注射次数。两组患者在 MRI 上的年龄和狭窄程度相匹配。

结果

两组患者在注射前到随访时的 VAS 评分之间无统计学差异(P=0.919)。椎板间和经椎间孔组之间重复注射次数的差异无统计学意义(0.91-平均 2.47 和 2.58)。椎板间和经椎间孔组的 VAS 评分均在注射前、注射后和随访时均有显著改善。接受手术的患者人数较少(椎板间组为 11%,经椎间孔组为 15%,无统计学意义,P=0.63)。

结论

在本研究中,与经椎间孔或椎板间注射相比,经椎间孔或椎板间注射在短期疼痛改善或长期手术干预或重复注射方面均未显示出优势。

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