在细菌信使核糖核酸（mRNA）降解过程中，结果决定方式。
The end defines the means in bacterial mRNA decay.
作者信息
Schoenberg Daniel R
出版信息
Nat Chem Biol. 2007 Sep;3(9):535-6. doi: 10.1038/nchembio0907-535.
Abstract
Bacterial mRNAs begin with a triphosphate on the first transcribed nucleotide, but the endonuclease long thought to initiate mRNA decay in E. coli (RNase E) only works well on RNA with a 5′ monophosphate. The first committed step in the degradation of mRNA in that organism now appears to be the conversion of the 5′ triphosphate to a monophosphate, a process that is functionally similar to mRNA decapping in eukaryotes.
摘要
细菌mRNA在第一个转录核苷酸上起始于三磷酸，但长期以来被认为启动大肠杆菌中mRNA降解的核酸内切酶（核糖核酸酶E）仅对具有5′单磷酸的RNA有效。现在看来，该生物体中mRNA降解的第一个关键步骤是将5′三磷酸转化为单磷酸，这一过程在功能上类似于真核生物中的mRNA脱帽。
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