[卡比啶对肾上腺素能神经传递过程的影响]

[Effect of carbidine on the process of adrenergic neurotransmission].

作者信息

Arefolov V A, Panasiuk L V

出版信息

Biull Eksp Biol Med. 1975 Jun;79(6):66-9.

Abstract

Methods of physiological analysis were applied to a study of the effect of an original psychotropic agent--carbidine--on the process of adrenergic neurotransmission on a model of an isolated rat Vas deferens. The noradrenaline (NA) content was determined in the same ductus spectrofluorimetrically; the capacity of the neuroleptic to block the consumption of the exogenous NA by the tissue was also investigated. Carbidine proved to possess an adrenomimetic effect caused by it capacity to release NA, leading to a reduction of endogenous neuromediator stores.

摘要

运用生理学分析方法，以离体大鼠输精管为模型，研究了一种新型精神药物——卡比定对肾上腺素能神经传递过程的影响。用荧光分光光度法测定同一输精管中的去甲肾上腺素（NA）含量；还研究了该抗精神病药物阻断组织对外源性NA消耗的能力。结果证明，卡比定具有拟肾上腺素作用，这是由于它能够释放NA，导致内源性神经介质储备减少。

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