孕中期流产使用米非司酮-米索前列醇的间隔为1至2天。

One or two day mifepristone-misoprostol interval for second trimester abortion.

作者信息

Nilas Lisbeth, Glavind-Kristensen Marianne, Vejborg Thomas, Knudsen Ulla Breth

机构信息

Department of Obstetrics and Gynecology, Hvidovre Hospital, Denmark.

出版信息

Acta Obstet Gynecol Scand. 2007;86(9):1117-21. doi: 10.1080/00016340701505002.

DOI:10.1080/00016340701505002

PMID:17712654

Abstract

METHODS

A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h.

RESULTS

The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001).

CONCLUSION

The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.

摘要

方法

对127名妊娠13至24周且胎儿存活、寻求人工流产的女性进行了一项为期2年的回顾性队列研究。目的是比较口服米非司酮（200毫克）与每3小时阴道给予米索前列醇（400微克）之间间隔1天和间隔2天的效果。

结果

1天组胎儿排出时间比2天组长（9.8小时对7.5小时；p<0.01），但两组的用药中位数相同，两组98%的流产均在24小时内发生。与妊娠时间较短的女性相比，妊娠17至22周的女性流产时间更长（10.2小时对6.8小时；p<0.001），未产妇的流产时间比经产妇更长（10.0小时对6.7小时；p<0.001）。