Kovalchuk Leonid V, Gankovskaya Ludmila V, Gankovskaya Oksana A, Lavrov Vyacheslav F
Russian State Medical University, Department of Immunology, Moscow, Russia.
Adv Exp Med Biol. 2007;601:369-76. doi: 10.1007/978-0-387-72005-0_39.
The herpes virus infection represents a significant challenge for public health. The innate immunity plays an important role in herpes simplex virus (HSV) elimination. The innate antiviral immunity has not been comprehensively studied. The recent investigations demonstrate that Toll-like receptors are actively involved in the virus recognition. The complement and natural antibodies, as well as cytokines and antimicrobial peptides, are the first molecules to bind to virions. In this chapter, some mechanisms of the innate antiviral immunity are discussed and treatment regimens are proposed. The complex of native cytokines and antimicrobial peptides (CCAP or Superlymph) proved to inhibit the virus reproduction in vitro. Protegrines, as a CCAP component, were active against the virus. Considering all the data, we conclude that the complex of native cytokines and antimicrobial peptides produces both immunomodulating and antiviral effects.
疱疹病毒感染对公共卫生构成重大挑战。先天免疫在单纯疱疹病毒（HSV）清除中发挥重要作用。先天抗病毒免疫尚未得到全面研究。最近的研究表明，Toll样受体积极参与病毒识别。补体和天然抗体，以及细胞因子和抗菌肽，是最先与病毒粒子结合的分子。在本章中，讨论了先天抗病毒免疫的一些机制并提出了治疗方案。天然细胞因子和抗菌肽复合物（CCAP或Superlymph）在体外可抑制病毒繁殖。作为CCAP组分的防御素对该病毒具有活性。综合所有数据，我们得出结论，天然细胞因子和抗菌肽复合物具有免疫调节和抗病毒作用。
