Liu Fang, Zhou Xiaolian, Cui Fengping, Jia Demin
College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Jun;24(3):595-8.
Poly (hydroxyethyl methacrylate) (PHEMA) hydrogel for intraocular lens (IOL) materials was synthesized by solution polymerization using 2-hydroxyethyl methacrylate (HEMA) as raw material, ammonium persulfate and sodium pyrosulfite (KPS/SMBS) as catalyst, and trietyleneglycole dimethacrylate (TEGDMA) as cross-linking additive. Effects of reaction time, temperature, dosage of catalyst and cross-linking additive on mechanical strength and the equilibrium water content (EWC) of the PHEMA hydrogel were systematically investigated and their structure and optical property were also characterized. The experimental results showed that the optimum conditions for preparing PHEMA hydrogel are: catalyst 0.5 wt%, cross-linking additive 1.0 wt%, reaction temperature 40 degrees C, reaction time 36 h. Under the optimum conditions, the tensile strength of PHEMA hydrogel prepared is as high as 0.57 MPa, hardness of Shore A is 23.0, EWC is over 40%, and light transmittance is over 97%.
以甲基丙烯酸羟乙酯（HEMA）为原料，过硫酸铵和焦亚硫酸钠（KPS/SMBS）为催化剂，三乙二醇二甲基丙烯酸酯（TEGDMA）为交联添加剂，通过溶液聚合反应合成了用于人工晶状体（IOL）材料的聚甲基丙烯酸羟乙酯（PHEMA）水凝胶。系统研究了反应时间、温度、催化剂用量和交联添加剂用量对PHEMA水凝胶机械强度和平衡含水量（EWC）的影响，并对其结构和光学性能进行了表征。实验结果表明，制备PHEMA水凝胶的最佳条件为：催化剂0.5 wt%，交联添加剂1.0 wt%，反应温度40℃，反应时间36 h。在最佳条件下，制备的PHEMA水凝胶的拉伸强度高达0.57 MPa，邵氏A硬度为23.0，EWC超过40%，透光率超过97%。
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