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[神经免疫调节:神经系统与免疫系统之间的相互作用]

[Neuroimmunomodulation: the cross-talk between nervous and immune systems].

作者信息

Alves Glaucie Jussilane, Palermo-Neto João

机构信息

Fundação de Amparo à Pesquisa do Estado de São Paulo, Brasil.

出版信息

Braz J Psychiatry. 2007 Dec;29(4):363-9. doi: 10.1590/s1516-44462006005000052. Epub 2008 Jan 8.

DOI:10.1590/s1516-44462006005000052
PMID:17713698
Abstract

OBJECTIVE

Several papers arriving from the neuroimmunomodulation field are showing the relevant relationships between the nervous and the immune systems. A review of studies was carried out to describe the bases of the studies on neuroimmunomodulation.

EXPERIMENTAL MODELS

It is clear nowadays that emotional states such as anxiety and depression change immune system activity, an affect also observed after both stress and use of nervous system acting drugs.

SICK BEHAVIOR

The behavior displayed by sick organisms might be thought as being a consequence of homeostatic strategies.

POSSIBLE MECHANISM OF THE ACTION BY MEANS OF IMMUNE SYSTEM TO NERVOUS SYSTEM

A very big emphasis is being given to Hipothalamus-pituitary-adrenal axis, sympathetic nervous system and cytokines participation on nervous system and immune system relationships.

CONCLUSION

The present revision intend to show some essential studies in the neuroimmunomodulation field; it makes a critical analysis of the mutual relationships between nervous system and immune system.

摘要

目的

来自神经免疫调节领域的几篇论文展示了神经系统与免疫系统之间的相关关系。开展了一项研究综述以描述神经免疫调节研究的基础。

实验模型

如今很明显,焦虑和抑郁等情绪状态会改变免疫系统活动,在应激和使用作用于神经系统的药物后也观察到了这种影响。

患病行为

患病生物体表现出的行为可能被认为是稳态策略的结果。

免疫系统对神经系统作用的可能机制

下丘脑 - 垂体 - 肾上腺轴、交感神经系统和细胞因子在神经系统与免疫系统关系中的参与受到了极大关注。

结论

本次综述旨在展示神经免疫调节领域的一些重要研究;对神经系统与免疫系统之间的相互关系进行批判性分析。

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