Miller A H
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Psychiatr Clin North Am. 1998 Jun;21(2):443-63. doi: 10.1016/s0193-953x(05)70015-0.
Based on the extensive characterization of communication pathways between the nervous system and the immune system, there has been increasing interest in the impact of the nervous system on the development and expression of disorders involving the immune system and the contribution of the immune system to psychiatric disease. A vast literature has documented the impact of various stressors on a wide array of immune partners, and the specific neuroendocrine pathways involved have been elucidated. The impact of cytokines on neuroendocrine function and behavior has also been determined, and the relevance of cytokines to the pathophysiology of depression has become an exciting new research frontier. This article provides a foundation for integrating neuroendocrine-immune interactions into the formulation of neuropsychiatric and immunologic disease.
基于对神经系统与免疫系统之间通信通路的广泛表征，人们越来越关注神经系统对涉及免疫系统的疾病的发生和表现的影响，以及免疫系统对精神疾病的作用。大量文献记录了各种应激源对众多免疫相关因素的影响，并且已经阐明了其中涉及的特定神经内分泌途径。细胞因子对神经内分泌功能和行为的影响也已得到确定，细胞因子与抑郁症病理生理学的相关性已成为一个令人兴奋的新研究前沿。本文为将神经内分泌-免疫相互作用纳入神经精神疾病和免疫疾病的形成机制提供了一个基础。
