Engin Aynur, Yildirim Altan, Kunt Tanfer, Bakir Mehmet, Dokmetas Ilyas, Ozdemir Levent
Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
Int J Infect Dis. 2008 Mar;12(2):162-5. doi: 10.1016/j.ijid.2007.06.003. Epub 2007 Aug 21.
The aim of this study was to investigate cochlear damage in Crimean-Congo hemorrhagic fever (CCHF) infection.
Thirty-two CCHF patients (study group) and 13 healthy people (controls) were included in the study. CCHF patients were also grouped for the presence of fever. CCHF was diagnosed with the presence of CCHF virus-specific IgM antibody or CCHF virus (CCHFV) antigen by ELISA. Cochlear damage was determined by a 'fail' in the transient evoked otoacoustic emission (TEOAE) test.
The proportion of TEOAE test 'fail' results in the CCHF patients was significantly higher than in the control group (p<0.05). We found no increase in the proportion of TEOAE test 'fail' results related to fever in the study group.
CCHF disease damages cochlear function regardless of fever.
本研究旨在调查克里米亚-刚果出血热（CCHF）感染中的耳蜗损伤情况。
本研究纳入了32例CCHF患者（研究组）和13名健康人（对照组）。CCHF患者还根据发热情况进行了分组。通过酶联免疫吸附测定法（ELISA）检测到CCHF病毒特异性IgM抗体或CCHF病毒（CCHFV）抗原，从而确诊CCHF。通过瞬态诱发耳声发射（TEOAE）测试中的“失败”来确定耳蜗损伤。
CCHF患者中TEOAE测试“失败”结果的比例显著高于对照组（p<0.05）。我们发现研究组中与发热相关的TEOAE测试“失败”结果比例没有增加。
无论是否发热，CCHF疾病都会损害耳蜗功能。
