Eichinger M, Puderbach M, Smith H-J, Tetzlaff R, Kopp-Schneider A, Bock M, Biederer J, Kauczor H-U
Department of Radiology (E010), Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Eur Respir J. 2007 Nov;30(5):972-9. doi: 10.1183/09031936.00040607. Epub 2007 Aug 22.
The aim of this study was to assess the feasibility and accuracy of a novel magnetic resonance-compatible (MRc)-spirometer. The influence of body posture, magnetic resonance (MR)-setting and image acquisition on lung function was evaluated. Dynamic MR imaging (dMRI) was compared with simultaneously measured lung function. The development of the MRc-spirometer was based on a commercial spirometer and evaluated by flow-generator measurements and forced expiratory manoeuvres in 34 healthy nonsmokers (17 females and 17 males, mean age 32.9 yrs). Mean differences between forced expiratory volume in one second (FEV(1)) and forced vital capacity (FVC) were calculated and a sample paired t-test and Bland-Altman plots were generated. A total of 11 subjects underwent different subsequent MRc-spirometric measurements to assess the influence of the components of the MR system on lung function. The mean (95% confidence interval) difference of FEV(1) and FVC between the two systems was 0.004 (-0.04-0.04) L and 0.018 (-0.05-0.09) L, respectively. In the subgroup analysis, an influence of the MR-system on FEV(1) was found. FEV(1) correlated well with the dMRI measurement of the apico-diaphragmatic distance-change after the first second of forced expiration (r = 0.72). In conclusion, magnetic resonance-compatible-spirometry is feasible, reliable and safe. The magnetic resonance-setting only has a small influence on simultaneously measured forced expiratory volume in one second. Dynamic magnetic resonance imaging measurements correlate well with simultaneously acquired lung function parameters.
本研究的目的是评估一种新型磁共振兼容（MRc）肺活量计的可行性和准确性。评估了身体姿势、磁共振（MR）设置和图像采集对肺功能的影响。将动态磁共振成像（dMRI）与同时测量的肺功能进行比较。MRc肺活量计是基于商用肺活量计开发的，并通过流量发生器测量和34名健康非吸烟者（17名女性和17名男性，平均年龄32.9岁）的用力呼气动作进行评估。计算一秒用力呼气量（FEV(1)）和用力肺活量（FVC）之间的平均差异，并生成样本配对t检验和Bland-Altman图。共有11名受试者接受了不同的后续MRc肺活量测量，以评估MR系统组件对肺功能的影响。两个系统之间FEV(1)和FVC的平均（95%置信区间）差异分别为0.004（-0.04-0.04）L和0.018（-0.05-0.09）L。在亚组分析中，发现MR系统对FEV(1)有影响。FEV(1)与用力呼气第一秒后尖膈距离变化的dMRI测量值相关性良好（r = 0.72）。总之，磁共振兼容肺活量测定是可行、可靠和安全的。磁共振设置对同时测量的一秒用力呼气量影响较小。动态磁共振成像测量与同时获取的肺功能参数相关性良好。
