Roth L M, Pride G L, Sharma H M
Cancer. 1976 Apr;37(4):1725-36. doi: 10.1002/1097-0142(197604)37:4<1725::aid-cncr2820370418>3.0.co;2-1.
A müllerian adenosarcoma with heterologous elements having the gross appearance of a sarcoma botryoides occurred in the uterine cervix of a 14-year-old girl. Histologically, the tumor was composed of an admixture of benign-appearing glands and a sarcomatous stroma, the latter containing areas of undifferentiated sarcoma and endometrial stromal sarcoma, as well as heterologous elements consisting of rhabdomyosarcoma and hyaline cartilage. No malignant epithelial component was observed. The distribution of benign müllerian-type glands throughout the tumor simulated a malignant mixed müllerian tumor in appearance. Ultrastructural studies of the stromal elements of the neoplasm suggest origin from primitive müllerian stroma, and the glands have features of primitive müllerian epithelium. This study supports the concept that the malignant mixed müllerian tumor and related müllerian sarcomas originate from a common undifferentiated multipotential müllerian stem cell.
一名14岁女孩的子宫颈发生了具有葡萄状肉瘤大体外观的伴有异源性成分的苗勒管腺肉瘤。组织学上，肿瘤由外观良性的腺体和肉瘤样间质混合组成，后者包含未分化肉瘤和子宫内膜间质肉瘤区域，以及由横纹肌肉瘤和透明软骨组成的异源性成分。未观察到恶性上皮成分。肿瘤内良性苗勒管型腺体的分布在外观上模拟了恶性苗勒管混合瘤。对肿瘤间质成分的超微结构研究提示其起源于原始苗勒管间质，而腺体具有原始苗勒管上皮的特征。本研究支持恶性苗勒管混合瘤及相关苗勒管肉瘤起源于共同的未分化多能苗勒管干细胞这一概念。
