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日本米汤对蒙古沙鼠模型中幽门螺杆菌的体内杀菌活性。

In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model.

作者信息

Ishizone Satoshi, Maruta Fukuto, Suzuki Kazufumi, Miyagawa Shinichi, Takeuchi Masahiko, Kanaya Kiyomi, Oana Kozue, Hayama Masayoshi, Kawakami Yoshiyuki, Ota Hiroyoshi

机构信息

Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

Int J Med Sci. 2007 Aug 10;4(4):203-8. doi: 10.7150/ijms.4.203.

DOI:10.7150/ijms.4.203
PMID:17717596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1950273/
Abstract

PURPOSE

The antibiotic effect of rice-fluid on Helicobacter pylori infection was investigated using a Mongolian gerbil model.

METHODS

Gerbils were divided into four groups: H. pylori -infected, rice-fluid-treated animals (group A); H. pylori -infected, untreated animals (group B); uninfected, rice-fluid-treated animals (group C); and uninfected, untreated animals (group D). Group A and B animals were killed 14 weeks after H. pylori infection and group C and D animals were killed at the same age. The stomachs were examined for histology, 5'-bromo-2'-deoxyuridine (BrdU) labeling, and the bacterial burden. Serum anti-H. pylori antibody titers were also tested.

RESULTS

The positive incidence of H. pylori -culture was 25 and 84 % in groups A and B, respectively (p<0.01). Both the degree of inflammation and the BrdU labeling index in group A were significantly lower than those in group B.

CONCLUSIONS

Rice-fluid showed an antibiotic effect on H. pylori and an anti-inflammatory effect on the H. pylori -associated gastritis.

摘要

目的

使用蒙古沙鼠模型研究米汤对幽门螺杆菌感染的抗菌作用。

方法

将沙鼠分为四组：感染幽门螺杆菌且经米汤处理的动物（A组）；感染幽门螺杆菌但未处理的动物（B组）；未感染且经米汤处理的动物（C组）；未感染且未处理的动物（D组）。幽门螺杆菌感染14周后处死A组和B组动物，C组和D组动物在相同年龄处死。检查胃组织的组织学、5'-溴-2'-脱氧尿苷（BrdU）标记及细菌载量。还检测血清抗幽门螺杆菌抗体滴度。

结果

A组和B组幽门螺杆菌培养阳性率分别为25%和84%（p<0.01）。A组的炎症程度和BrdU标记指数均显著低于B组。

结论

米汤对幽门螺杆菌有抗菌作用，对幽门螺杆菌相关性胃炎有抗炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d8/1950273/13ae53a32603/ijmsv04p0203g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d8/1950273/688a4a08313b/ijmsv04p0203g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d8/1950273/19b67fb34e6b/ijmsv04p0203g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d8/1950273/13ae53a32603/ijmsv04p0203g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d8/1950273/688a4a08313b/ijmsv04p0203g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d8/1950273/19b67fb34e6b/ijmsv04p0203g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6d8/1950273/13ae53a32603/ijmsv04p0203g03.jpg

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