Subramanian Perumal, Mirunalini Shankaran, Pandi-Perumal Seithikurippu R, Trakht Ilya, Cardinali D P
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India.
Eur J Pharmacol. 2007 Oct 1;571(2-3):116-9. doi: 10.1016/j.ejphar.2007.06.011. Epub 2007 Jun 21.
This study examines the effect of a daily administration of melatonin for 45 days at two doses (0.5 and 1.0 mg/kg body wt.) on antioxidant status, lipid peroxidation and lipid profile in the brain and liver in rats. Both doses of melatonin caused a significant decrease in lipid peroxidation and the levels of cholesterol, phospholipids, triglycerides and free fatty acids in the examined tissues. Concomitantly, the treatment with melatonin augmented the activity of the brain and liver antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase as well as increased glutathione levels. These results offer a support to the hypothesis that melatonin in pharmacological amounts effectively reduces oxidative stress and acts as an antihyperlipidemic agent.
本研究考察了连续45天每日以两种剂量（0.5和1.0毫克/千克体重）给予褪黑素对大鼠脑和肝脏抗氧化状态、脂质过氧化及血脂水平的影响。两种剂量的褪黑素均使受试组织中的脂质过氧化以及胆固醇、磷脂、甘油三酯和游离脂肪酸水平显著降低。同时，褪黑素治疗增强了脑和肝脏抗氧化酶超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性，并提高了谷胱甘肽水平。这些结果支持了以下假说：药理剂量的褪黑素可有效减轻氧化应激并起到抗高脂血症药物的作用。
Zotero 插件