Wordinger Robert J, Clark Abbot F
Department of Cell Biology and Genetics, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107-2699, USA.
Exp Biol Med (Maywood). 2007 Sep;232(8):979-92. doi: 10.3181/0510-MR-345.
The human genome encodes at least 42 different members of the transforming growth factor-beta superfamily of growth factors. Bone morphogenetic proteins (BMPs) are the largest subfamily of proteins within the transforming growth factor-beta superfamily and are involved in numerous cellular functions including development, morphogenesis, cell proliferation, apoptosis, and extracellular matrix synthesis. This article first reviews BMPs and BMP receptors, BMP signaling pathways, and mechanisms controlling BMP signaling. Second, we review BMP and BMP receptor expression during embryonic ocular development/ differentiation and in adult ocular tissues. Lastly, future research directions with respect to BMP, BMP receptors, and ocular tissues are suggested.
人类基因组编码至少42种转化生长因子-β超家族的不同生长因子成员。骨形态发生蛋白（BMPs）是转化生长因子-β超家族中最大的蛋白质亚家族，参与多种细胞功能，包括发育、形态发生、细胞增殖、凋亡和细胞外基质合成。本文首先综述骨形态发生蛋白及其受体、骨形态发生蛋白信号通路以及控制骨形态发生蛋白信号的机制。其次，我们综述胚胎眼发育/分化过程以及成年眼组织中骨形态发生蛋白及其受体的表达情况。最后，提出关于骨形态发生蛋白、骨形态发生蛋白受体和眼组织的未来研究方向。
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