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An improved algorithm for clustering gene expression data.

作者信息

Bandyopadhyay Sanghamitra, Mukhopadhyay Anirban, Maulik Ujjwal

机构信息

Machine Intelligence Unit, Indian Statistical Institute, Kolkata-700108, India.

出版信息

Bioinformatics. 2007 Nov 1;23(21):2859-65. doi: 10.1093/bioinformatics/btm418. Epub 2007 Aug 25.


DOI:10.1093/bioinformatics/btm418
PMID:17720981
Abstract

MOTIVATION: Recent advancements in microarray technology allows simultaneous monitoring of the expression levels of a large number of genes over different time points. Clustering is an important tool for analyzing such microarray data, typical properties of which are its inherent uncertainty, noise and imprecision. In this article, a two-stage clustering algorithm, which employs a recently proposed variable string length genetic scheme and a multiobjective genetic clustering algorithm, is proposed. It is based on the novel concept of points having significant membership to multiple classes. An iterated version of the well-known Fuzzy C-Means is also utilized for clustering. RESULTS: The significant superiority of the proposed two-stage clustering algorithm as compared to the average linkage method, Self Organizing Map (SOM) and a recently developed weighted Chinese restaurant-based clustering method (CRC), widely used methods for clustering gene expression data, is established on a variety of artificial and publicly available real life data sets. The biological relevance of the clustering solutions are also analyzed.

摘要

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