• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

无血清培养基和二丁酰环磷腺苷对新生大鼠星形胶质细胞影响的超微结构比较研究

Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblasts.

作者信息

Moonen G, Heinen E, Goessens G

出版信息

Cell Tissue Res. 1976 Mar 16;167(2):221-7. doi: 10.1007/BF00224329.

DOI:10.1007/BF00224329
PMID:177214
Abstract

Modifications of cell shape induced in cultured newborn rat astroblasts by serum deprivation or dibutyryladenosine 3'-5' monophosphate (dBcAMP) are described. Serum suppression modifies the adhesitivity of the cells to the substrate, but this modification is not consistent with a true differentiation. The main ultrastructural feature of dBcAMP-treated astroblasts is the presence of an extensive system of 90 A microfilaments, while control cells are relatively devoid of these structures.

摘要

本文描述了血清剥夺或二丁酰腺苷 3'-5'-单磷酸（dBcAMP）诱导培养的新生大鼠星形胶质细胞发生的细胞形态改变。血清抑制改变了细胞与底物的黏附性，但这种改变与真正的分化不一致。经 dBcAMP 处理的星形胶质细胞的主要超微结构特征是存在广泛的 90 Å 微丝系统，而对照细胞相对缺乏这些结构。

相似文献

1
Comparative ultrastructural study of the effects of serum-free medium and dibutyryl-cyclic AMP on newborn rat astroblasts.无血清培养基和二丁酰环磷腺苷对新生大鼠星形胶质细胞影响的超微结构比较研究
Cell Tissue Res. 1976 Mar 16;167(2):221-7. doi: 10.1007/BF00224329.
2
Variability of the effects of serum-free medium, dibutyryl-cyclic AMP or theophylline on the morphology of cultured new-born rat astroblasts.无血清培养基、二丁酰环磷腺苷或茶碱对培养的新生大鼠星形胶质细胞形态影响的变异性
Cell Tissue Res. 1975 Nov 12;163(3):365-72. doi: 10.1007/BF00219470.
3
Effects of dibutyryl cyclic AMP on cultured brain cells from chick embryos of different ages.二丁酰环磷酸腺苷对不同年龄鸡胚培养脑细胞的影响。
Experientia. 1976 Jan 15;32(1):40-2. doi: 10.1007/BF01932612.
4
Organization of microfilaments in astrocytes that form in the presence of dibutyryl cyclic AMP in cultures, and which are similar to reactive astrocytes in vivo.在培养物中，在二丁酰环磷酸腺苷存在的情况下形成的星形胶质细胞中的微丝组织，其与体内反应性星形胶质细胞相似。
Neuroscience. 1987 Jul;22(1):255-66. doi: 10.1016/0306-4522(87)90216-8.
5
Ultrastructural changes accompanying the induced differentiation of clonal rat nerve and glia.
Neurobiology. 1975 Mar;5(1):1-7.
6
Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro.凝血酶及其抑制剂在体外调节星形胶质细胞的形态和生化分化。
Brain Res Dev Brain Res. 1990 Jun 1;54(1):93-104. doi: 10.1016/0165-3806(90)90069-b.
7
Dibutyryl cyclic AMP-induced morphological differentiation of rat brain astrocytes increases alpha 1-adrenoceptor induced phosphoinositide breakdown by a mechanism involving protein synthesis.二丁酰环磷腺苷诱导的大鼠脑星形胶质细胞形态分化通过一种涉及蛋白质合成的机制增加了α1-肾上腺素能受体诱导的磷酸肌醇分解。
Brain Res. 1993 Feb 5;602(2):318-24. doi: 10.1016/0006-8993(93)90696-k.
8
Effect of dibutyryl cyclic AMP on the kinetics of myo-inositol transport in cultured astrocytes.二丁酰环磷酸腺苷对培养星形胶质细胞中肌醇转运动力学的影响。
J Neurochem. 1999 Jul;73(1):105-11. doi: 10.1046/j.1471-4159.1999.0730105.x.
9
Protein synthesis in astrocytes: 'spontaneous' and cyclic AMP-induced differentiation.星形胶质细胞中的蛋白质合成：“自发”及环磷酸腺苷诱导的分化
Dev Neurosci. 1986;8(1):31-43. doi: 10.1159/000112239.
10
Herpes simplex virus type 1 infection of rat astrocytes in primary culture: effects of dibutyryl cyclic AMP.原代培养大鼠星形胶质细胞的单纯疱疹病毒1型感染：二丁酰环磷腺苷的作用
J Neuropathol Exp Neurol. 1990 Jan;49(1):3-20. doi: 10.1097/00005072-199001000-00002.

引用本文的文献

1
Validation of a System x Functional Assay in Cultured Astrocytes and Nervous Tissue Samples.培养星形胶质细胞和神经组织样本中系统x功能分析的验证
Front Cell Neurosci. 2022 Jan 13;15:815771. doi: 10.3389/fncel.2021.815771. eCollection 2021.
2
Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease.重要的变形者：发育、损伤和疾病过程中允许星形胶质细胞对不断变化的神经系统做出反应的机制。
Front Cell Neurosci. 2018 Aug 21;12:261. doi: 10.3389/fncel.2018.00261. eCollection 2018.
3
Transcriptional Regulation of Glutamate Transporters: From Extracellular Signals to Transcription Factors.

本文引用的文献

1
Induced differentiation of clonal rat nerve and glial cells.克隆大鼠神经和神经胶质细胞的诱导分化
Neurobiology. 1974;4(6):376-87.
2
Maturation-stimulation effect of brain extract and dibutyryl cyclic AMP on dissociated embryonic brain cells in culture.脑提取物和二丁酰环磷酸腺苷对培养的离体胚胎脑细胞的成熟刺激作用
Exp Cell Res. 1973 Apr;79(1):243-6.
3
Morphological and biochemical alterations in foetal rat brain cells cultured in the presence of monobutyryl cyclic AMP.在单丁酰环磷酸腺苷存在的情况下培养的胎鼠脑细胞的形态学和生化改变
谷氨酸转运体的转录调控：从细胞外信号到转录因子
Adv Pharmacol. 2016;76:103-45. doi: 10.1016/bs.apha.2016.01.004. Epub 2016 Mar 24.
4
A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation.AMP激活蛋白激酶（AMPK）的一种药理激活剂可诱导星形胶质细胞形成星状。
Brain Res. 2007 Sep 7;1168:1-10. doi: 10.1016/j.brainres.2007.06.087. Epub 2007 Jul 27.
5
Upregulation of neuronal nitric oxide synthase in in vitro stellate astrocytes and in vivo reactive astrocytes after electrically induced status epilepticus.电诱导癫痫持续状态后体外培养的星型胶质细胞和体内反应性星形胶质细胞中神经元型一氧化氮合酶的上调
Neurochem Res. 2003 Apr;28(3-4):607-15. doi: 10.1023/a:1022841911265.
6
Effects of maturation on the phospholipid and phospholipid fatty acid compositions in primary rat cortical astrocyte cell cultures.成熟对原代大鼠皮质星形胶质细胞培养物中磷脂及磷脂脂肪酸组成的影响。
Neurochem Res. 1997 Oct;22(10):1205-13. doi: 10.1023/a:1021924711675.
7
Characteristics of cultured subepithelial fibroblasts of rat duodenal villi.大鼠十二指肠绒毛培养的上皮下成纤维细胞的特征
Anat Embryol (Berl). 1993 Jun;187(6):529-38. doi: 10.1007/BF00214431.
8
Intracellular calcium responses and shape conversions induced by endothelin in cultured subepithelial fibroblasts of rat duodenal villi.内皮素诱导的大鼠十二指肠绒毛上皮下成纤维细胞内钙反应及形态转化
Pflugers Arch. 1994 Sep;428(2):97-104. doi: 10.1007/BF00374846.
9
Effects of norepinephrine and dibutyryl adenosine 3',5'-cyclic monophosphate on the ultrastructure of pineal cells in monolayer culture.去甲肾上腺素和二丁酰腺苷 3',5'-环磷酸对单层培养的松果体细胞超微结构的影响。
Cell Tissue Res. 1981;216(1):181-91. doi: 10.1007/BF00234553.
10
Cellular composition of a cerebral hemisphere primary culture.大脑半球原代培养物的细胞组成。
Neurochem Res. 1984 Feb;9(2):153-72. doi: 10.1007/BF00964164.
Nature. 1973 Jan 19;241(5386):203-4. doi: 10.1038/241203a0.
4
The responses in culture of human tumour astrocytes and neuroblasts to N 6 , O 2' -dibutyryl adenosine 3',5'-monophosphoric acid.人肿瘤星形胶质细胞和成神经细胞培养物对N6，O2'-二丁酰腺苷3'，5'-单磷酸的反应。
J Cell Sci. 1972 Nov;11(3):639-67. doi: 10.1242/jcs.11.3.639.
5
Effects of dibutyryl cyclic AMP and prostaglandin E1 on cultured human glioma cells.
Exp Cell Res. 1974 Mar 30;85(1):217-23. doi: 10.1016/0014-4827(74)90233-x.
6
Variability of the effects of serum-free medium, dibutyryl-cyclic AMP or theophylline on the morphology of cultured new-born rat astroblasts.无血清培养基、二丁酰环磷腺苷或茶碱对培养的新生大鼠星形胶质细胞形态影响的变异性
Cell Tissue Res. 1975 Nov 12;163(3):365-72. doi: 10.1007/BF00219470.
7
Ultrastructural changes accompanying the induced differentiation of clonal rat nerve and glia.
Neurobiology. 1975 Mar;5(1):1-7.