Monteleone P, Artini P G, Simi G, Cela V, Casarosa E, Begliuomini S, Ninni F, Pluchino N, Luisi M, Genazzani A R
Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
J Assist Reprod Genet. 2007 Oct;24(10):477-80. doi: 10.1007/s10815-007-9169-y. Epub 2007 Aug 25.
The aim of the study was to measure circulating BDNF levels, a neurotrophin recently identified in the ovary, in parallel with estradiol, to verify if assessing this factor could add any predictive value to the outcome of in vitro fertilization.
Blood sampling for BDNF and estradiol was performed in 23 subjects undergoing IVF on day 1 (D1), day 8 (D8), day of HCG administration (DHCG) and day of oocyte retrieval.(DOR).
There was a positive correlation between BDNF and estradiol throughout the stimulation cycle in all subjects. In both pregnant and nonpregnant patients, the values of BDNF grew significantly only between D8 and DHCG and remained constant until DOR. Between-group comparisons showed no statistically significant differences in both BDNF and estradiol values throughout the IVF cycle.
Although BDNF plasma concentrations are not seemingly predictive of IVF outcome, this neurotrophin is highly correlated to estradiol levels and seems to be an important factor especially in the periovulatory period.
本研究旨在测量循环中的脑源性神经营养因子（BDNF）水平，这是一种最近在卵巢中发现的神经营养因子，同时测量雌二醇水平，以验证评估该因子是否能为体外受精的结果增加任何预测价值。
对23名接受体外受精的受试者在第1天（D1）、第8天（D8）、注射人绒毛膜促性腺激素当天（DHCG）和取卵当天（DOR）采集血液样本，检测BDNF和雌二醇水平。
在所有受试者的整个刺激周期中，BDNF与雌二醇之间存在正相关。在怀孕和未怀孕的患者中，BDNF值仅在D8和DHCG之间显著升高，并一直保持到DOR。组间比较显示，在整个体外受精周期中，BDNF和雌二醇值均无统计学显著差异。
虽然BDNF血浆浓度似乎不能预测体外受精的结果，但这种神经营养因子与雌二醇水平高度相关，似乎是一个重要因素，尤其是在排卵前期。
