体外受精周期中血清瘦素、卵泡液瘦素、雌二醇和孕酮水平的作用。
The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle.
作者信息
Hill Micah J, Uyehara Catherine F T, Hashiro Glenn M, Frattarelli John L
机构信息
Tripler Army Medical Center, Honolulu, HI, USA.
出版信息
J Assist Reprod Genet. 2007 May;24(5):183-8. doi: 10.1007/s10815-007-9106-0. Epub 2007 Mar 1.
Abstract
PURPOSE
To prospectively evaluate serum and follicular fluid leptin, estradiol, and progesterone levels during in vitro fertilization.
METHODS
Prospective observational study measuring serum levels at six points during the IVF cycle and follicular fluid at the time of retrieval.
RESULTS
Serum leptin and estradiol levels both significantly increased for the individual patients during the IVF stimulation process. None of the leptin levels differed based on pregnancy outcome. BMI significantly correlated with all leptin levels. Follicular fluid estradiol correlated with serum estradiol only in pregnant patients (r = 0.97, p<0.01) and was unrelated in non-pregnant patients (r=-0.15, p=0.81).
CONCLUSION
Serum and follicular leptin levels are highly correlated. Leptin levels increase during the IVF cycle and vary between patients based on maternal BMI, but do not correlate with other serum hormone levels or pregnancy outcome. Pregnancy outcome success was reflected in the relationship between follicular fluid and serum levels of estradiol, independent of leptin levels.
摘要
目的
前瞻性评估体外受精过程中血清和卵泡液中瘦素、雌二醇和孕酮水平。
方法
前瞻性观察性研究，在体外受精周期的六个时间点测量血清水平，并在取卵时测量卵泡液水平。
结果
在体外受精刺激过程中，个体患者的血清瘦素和雌二醇水平均显著升高。瘦素水平在妊娠结局方面无差异。体重指数与所有瘦素水平显著相关。卵泡液雌二醇仅在妊娠患者中与血清雌二醇相关（r = 0.97，p<0.01），在未妊娠患者中无相关性（r=-0.15，p=0.81）。
结论
血清和卵泡瘦素水平高度相关。瘦素水平在体外受精周期中升高，且因母体体重指数不同而在患者间存在差异，但与其他血清激素水平或妊娠结局无关。妊娠结局的成功反映在卵泡液与血清雌二醇水平之间的关系上，与瘦素水平无关。
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