Edelstein Michael L, Abedi Mohammad R, Wixon Jo
Hemel Hempstead Hospital, Hillfield Road, Hemel Hempstead HP2 4AD, UK.
J Gene Med. 2007 Oct;9(10):833-42. doi: 10.1002/jgm.1100.
To date, over 1340 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. In 1997 we set up a database to bring together global information on gene therapy clinical trials as comprehensively as possible. The data are compiled and regularly updated from official agency sources, published literature, conference presentations and posters and from information kindly provided by investigators or trial sponsors themselves. This review updates our descriptive overview of the data in 2004 1, presenting our analysis of the clinical trials that, to the best of our knowledge, have been or are being performed worldwide. As of July 30 2007, we have stored entries on 1309 trials in 28 countries. We have analyzed the geographical distribution of trials, the disease indications (or other reasons) for trials, the proportions to which different vector types are used, and which genes have been transferred. Details of the analyses presented, and our interactive, searchable database can be found on The Journal of Gene Medicine Gene Therapy Clinical Trials Worldwide website at: http://www.wiley.co.uk/genmed/clinical.
迄今为止，全球已完成、正在进行或已获批的基因治疗临床试验超过1340项。1997年，我们建立了一个数据库，尽可能全面地汇总全球基因治疗临床试验信息。数据来自官方机构来源、已发表文献、会议报告和海报，以及研究人员或试验申办方自行提供的信息，并进行汇编和定期更新。本综述更新了我们在2004年对数据的描述性概述，呈现了我们对据我们所知在全球已开展或正在开展的临床试验的分析。截至2007年7月30日，我们已存储了28个国家1309项试验的条目。我们分析了试验的地理分布、试验的疾病适应症（或其他原因）、不同载体类型的使用比例以及已转移的基因。所呈现分析的详细内容以及我们可交互式搜索的数据库可在《基因医学杂志》全球基因治疗临床试验网站上找到：http://www.wiley.co.uk/genmed/clinical 。
