帕金森病的时间干扰、纳米颗粒、超声、基因治疗及定制受体综述。

Currie A D, Wong J K, Okun M S

Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.

NPJ Parkinsons Dis. 2024 Oct 23;10(1):195. doi: 10.1038/s41531-024-00804-0.

In this review, we summarize preclinical and clinical trials investigating innovative neuromodulatory approaches for Parkinson disease (PD) motor symptom management. We highlight the following technologies: temporal interference, nanoparticles for drug delivery, blood-brain barrier opening, gene therapy, optogenetics, upconversion nanoparticles, magnetothermal nanoparticles, magnetoelectric nanoparticles, ultrasound-responsive nanoparticles, and designer receptors exclusively activated by designer drugs. These studies establish the basis for novel and promising neuromodulatory treatments for PD motor symptoms.

在本综述中，我们总结了研究用于帕金森病（PD）运动症状管理的创新神经调节方法的临床前和临床试验。我们重点介绍了以下技术：时间干扰、用于药物递送的纳米颗粒、血脑屏障开放、基因治疗、光遗传学、上转换纳米颗粒、磁热纳米颗粒、磁电纳米颗粒、超声响应纳米颗粒以及仅由设计药物激活的设计受体。这些研究为治疗PD运动症状的新型且有前景的神经调节疗法奠定了基础。