Rovio Suvi, Kåreholt Ingemar, Viitanen Matti, Winblad Bengt, Tuomilehto Jaakko, Soininen Hilkka, Nissinen Aulikki, Kivipelto Miia
Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden.
Int J Geriatr Psychiatry. 2007 Sep;22(9):874-82. doi: 10.1002/gps.1755.
Leisure-time physical activity has been related with a reduced risk of dementia and Alzheimer's disease (AD). The effects of occupational and commuting physical activity (physical activity at work and on the way to work) on cognitive health are still unclear. This study aimed to clarify the association between work-related physical activity and dementia/AD.
Participants of the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study were derived from random, population-based samples previously studied in a survey carried out in 1972, 1977, 1982, or 1987. After an average follow-up of 21 years, 1449 individuals (73%) aged 65 to 79 years participated in the re-examination in 1998.
Neither occupational [Odds Ratio (OR) 1.45; 95% Confidence Intervals (CI) 0.66-3.17] nor commuting physical activity (OR 0.46; 95% CI 0.10-2.17) were associated with the risk of dementia or AD after adjustments for age, sex, education, follow-up time, locomotor symptoms, main occupation during life, income at midlife, leisure-time physical activity, other subtype of work-related physical activity, ApoE genotype, vascular disorders and the smoking status. There were also no interactions between work-related physical activity and the ApoE epsilon4 genotype, leisure-time physical activity or sex.
In this study, work-related physical activity was not found to be sufficient to protect against dementia and AD later in life. The lack of effect might be partly due to a residual confounding. Nevertheless, physical activity during leisure-time may be beneficial even for people who are physically active at work or when commuting.
休闲时间的体育活动与痴呆症和阿尔茨海默病(AD)风险降低有关。职业和通勤体育活动(工作及上班途中的体育活动)对认知健康的影响仍不明确。本研究旨在阐明与工作相关的体育活动与痴呆症/AD之间的关联。
心血管危险因素、衰老与痴呆(CAIDE)研究的参与者来自于1972年、1977年、1982年或1987年进行的一项调查中先前研究的基于人群的随机样本。经过平均21年的随访,1449名年龄在65至79岁之间的个体(73%)于1998年参与了复查。
在对年龄、性别、教育程度、随访时间、运动症状、一生中的主要职业、中年收入、休闲时间体育活动、其他与工作相关的体育活动亚型、ApoE基因型、血管疾病和吸烟状况进行调整后,职业体育活动[比值比(OR)1.45;95%置信区间(CI)0.66 - 3.17]和通勤体育活动(OR 0.46;95% CI 0.10 - 2.17)均与痴呆症或AD风险无关。与工作相关的体育活动与ApoE ε4基因型、休闲时间体育活动或性别之间也没有相互作用。
在本研究中,未发现与工作相关的体育活动足以预防晚年的痴呆症和AD。缺乏这种作用可能部分归因于残余混杂因素。然而,即使对于在工作或通勤时体力活动较多的人来说,休闲时间的体育活动可能也是有益的。