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[妊娠末期母猪体内的母体和胎儿皮质类固醇]

[Maternal and fetal corticosteroids in the sow at the end of gestation].

作者信息

Fèvre J

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 Dec 22;281(24):2009-12.

PMID:177224
Abstract

Foetal and maternal blood samples are taken on the sow at the end of pregnancy. No variations in maternal cortisol are found, but plasma cortisol levels in the foetus, which are relatively constant between days 70 and 100 of pregnancy (10 to 20 ng/ml), increase suddenly at the end of pregnancy reaching a mean of 210 ng/ml at birth. This high increase of foetal corticosteroids at birth, similar to that found in other species (ewe, goat, etc.), probably plays a role in the mechanisms releasing parturition. It also permits us to understand the action of ACTH which induces premature birth when given to the pig foetus in the last days of pregnancy.

摘要

在妊娠末期采集母猪的胎儿和母体血液样本。未发现母体皮质醇有变化,但胎儿血浆皮质醇水平在妊娠70至100天之间相对恒定(10至20纳克/毫升),在妊娠末期突然升高,出生时平均达到210纳克/毫升。出生时胎儿皮质类固醇的这种大幅增加,类似于在其他物种(母羊、山羊等)中发现的情况,可能在分娩发动机制中起作用。这也使我们能够理解促肾上腺皮质激素(ACTH)的作用,在妊娠最后几天给猪胎儿注射ACTH会导致早产。

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