Dalle M, Delost P
J Endocrinol. 1979 Jul;82(1):43-51. doi: 10.1677/joe.0.0820043.
The metabolism and the rate of transfer of cortisol across the placenta in pregnant guinea-pigs and foetuses were studied by constant intravenous infusions of tritium-labelled cortisol. Estimates of endogenous and radioactive plasma cortisol levels were used to calculate the following parameters at four stages before parturition (days 62, 64, 66 and 67; parturition occurring at day 68): metabolic clearance rate; production rate; adrenal secretory rate; transfer rate from mother to foetus and from foetus to mother; irreversible removal rate; the fraction of cortisol derived from the other in the foetal and maternal vascular compartments; the fraction of secreted and recycled cortisol involved in the transfer. The metabolic clearance rate and the rates of production and secretion of cortisol were higher in the mother than in the foetus between days 62 and 67 of gestation. About 90% of the foetal cortisol was of maternal origin. The fraction of maternal cortisol of foetal origin increased in the last days of gestation.
通过持续静脉输注氚标记的皮质醇，研究了妊娠豚鼠和胎儿体内皮质醇的代谢以及皮质醇跨胎盘的转运速率。利用内源性和放射性血浆皮质醇水平的估计值，在分娩前的四个阶段（第62、64、66和67天；分娩发生在第68天）计算以下参数：代谢清除率；生成率；肾上腺分泌率；从母体到胎儿以及从胎儿到母体的转运率；不可逆清除率；胎儿和母体血管腔室中源自另一方的皮质醇比例；参与转运的分泌和循环皮质醇比例。在妊娠第62天至67天期间，母体中皮质醇的代谢清除率以及生成和分泌速率高于胎儿。约90%的胎儿皮质醇源自母体。源自胎儿的母体皮质醇比例在妊娠最后几天增加。
