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儿童膀胱及前列腺横纹肌肉瘤的保守治疗:非根治性手术的可能性

[Conservative treatment of bladder and prostatic rhabdomyosarcoma in childhood: possibilities for non-radical surgery].

作者信息

Julián Mora M, Extramiana J, Arrizabalaga M, Navarro J, Mañas A, Gonzalez P, Pérez M J, Paniagua P

机构信息

Servicio de Urología, Hospital de Móstoles, Madrid, España.

出版信息

Arch Esp Urol. 1991 Jul-Aug;44(6):719-24.

PMID:1772276
Abstract

Treatment of rhabdomyosarcoma (RMS) of the bladder and prostate has always been difficult. Despite the significant advancements that have permitted cure, there is no agreement in the choice and order of the different therapeutic options. We reviewed the available literature evaluating the role of non-radical surgery and attempts at bladder preservation especially in children. Partial resection with sufficient margin of safety is only possible in 20% of the primary bladder tumors and the 3-year survival rate is 80%, similar to the overall survival rate for tumors localized to this site. The excellent results achieved in the case described herein underscores the possibilities of a conservative treatment modality in well-selected cases. The patient, who was submitted to partial cystectomy and received VAC polychemotherapy for a period of one year, is alive, tumor free and has preserved bladder function 50 months post-operatively.

摘要

膀胱和前列腺横纹肌肉瘤(RMS)的治疗一直颇具难度。尽管在治疗方面已取得显著进展,使得治愈成为可能,但在不同治疗方案的选择和顺序上仍未达成共识。我们回顾了现有文献,评估非根治性手术的作用以及膀胱保留尝试,尤其是在儿童患者中的情况。对于原发性膀胱肿瘤,仅有20%的病例能够进行具有足够安全切缘的部分切除术,其3年生存率为80%,与局限于该部位肿瘤的总体生存率相似。本文所述病例取得的优异结果突显了在精心挑选的病例中采用保守治疗方式的可能性。该患者接受了部分膀胱切除术,并接受了为期一年的VAC联合化疗,术后50个月仍存活,无肿瘤且保留了膀胱功能。

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