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关节镜下自体骨软骨移植治疗膝关节软骨缺损:至少7年随访的前瞻性研究结果

Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up.

作者信息

Marcacci Maurilio, Kon Elizaveta, Delcogliano Marco, Filardo Giuseppe, Busacca Maurizio, Zaffagnini Stefano

机构信息

Rizzoli Orthopedic Institute, Bologna, Italy.

出版信息

Am J Sports Med. 2007 Dec;35(12):2014-21. doi: 10.1177/0363546507305455. Epub 2007 Aug 27.

Abstract

BACKGROUND

Articular cartilage lesions, with their inherent limited healing potential, remain a challenging problem for orthopaedic surgeons. Various approaches have been proposed to treat these lesions; nevertheless, opinions on indications and clinical efficacy of these techniques are still controversial.

PURPOSE

To evaluate the outcome of osteochondral autografts for treatment of femoral condyle cartilage lesions at a medium-to long-term follow-up.

STUDY DESIGN

Case series; Level of evidence, 4.

METHODS

We prospectively evaluated 30 patients (mean age, 29.3 years) with full-thickness knee chondral lesions (<2.5 cm(2)) treated with arthroscopic autologous osteochondral transplantation. Thirteen patients underwent previous surgery, while 17 patients were operated on for the first time. In 19 patients, associated procedures were performed. All patients were evaluated at 2- and 7-year follow-up. The International Cartilage Repair Society form, Tegner score, and magnetic resonance imaging were used for clinical evaluation.

RESULTS

The International Cartilage Repair Society objective evaluation showed 76.7% of patients had good or excellent results at 7-year follow-up, and International Knee Documentation Committee subjective score significantly improved from preoperative (34.8) to 7-year follow-up (71.8). The Tegner evaluation showed a significant improvement after the surgery at 2- and 7-year follow-up (from 2.9 to 6.2 and 5.6, respectively); however, we noticed reduced sports activity from 2- to 7-year follow-up. Magnetic resonance imaging evaluation showed good integration of the graft in the host bone and complete maintenance of the grafted cartilage in more than 60% of cases.

CONCLUSION

The results of this technique at medium- to long-term follow-up are encouraging. This arthroscopic 1-step surgery appears to be a valid solution for treatment of small, grade III to IV cartilage defects.

摘要

背景

关节软骨损伤因其固有的有限愈合潜能,仍然是骨科医生面临的一个具有挑战性的问题。已经提出了各种方法来治疗这些损伤;然而,关于这些技术的适应症和临床疗效的观点仍存在争议。

目的

在中长期随访中评估自体骨软骨移植治疗股骨髁软骨损伤的结果。

研究设计

病例系列;证据等级,4级。

方法

我们前瞻性评估了30例全层膝关节软骨损伤(<2.5 cm²)患者(平均年龄29.3岁),这些患者接受了关节镜下自体骨软骨移植。13例患者曾接受过手术,而17例患者首次接受手术。19例患者还进行了相关手术。所有患者均在2年和7年随访时进行评估。使用国际软骨修复协会表格、Tegner评分和磁共振成像进行临床评估。

结果

国际软骨修复协会的客观评估显示,76.7%的患者在7年随访时结果为良好或优秀,国际膝关节文献委员会主观评分从术前(34.8)显著提高到7年随访时(71.8)。Tegner评估显示,在2年和7年随访时手术后有显著改善(分别从2.9提高到6.2和5.6);然而,我们注意到从2年到7年随访期间体育活动减少。磁共振成像评估显示,在超过60%的病例中,移植骨与宿主骨良好整合,移植软骨完全保持。

结论

该技术在中长期随访中的结果令人鼓舞。这种关节镜下一步手术似乎是治疗小面积III至IV级软骨缺损的有效解决方案。

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