具有强效选择性心动过缓作用的呫吨酮-1,4-二氢吡啶衍生物。
Xanthone 1,4-dihydropyridine derivatives with a potent selective bradycardic effect.
作者信息
Valenti P, Chiarini A, Gasperi F, Budriesi R
机构信息
Department of Pharmaceutical Sciences, University of Bologna, Italy.
出版信息
Arzneimittelforschung. 1990 Feb;40(2 Pt 1):122-5.
PMID:2334451
Abstract
A series of xanthone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The tested compounds are weak calcium antagonists but exert potent selective bradycardic effects.
摘要
制备了一系列呫吨酮-1,4-二氢吡啶衍生物。对这些化合物的变力性、变时性和钙拮抗特性进行了评估。所测试的化合物是弱钙拮抗剂，但具有强效的选择性心动过缓作用。
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