Hzhehots'kyĭ M R, Panina L V, Terlets'ka O I, Koval'chuk S M
Fiziol Zh (1994). 2007;53(3):70-7.
Free radical homeostasis parameters of rat's brain mitochondria under conditions of sodium nitrite administration at the peak of hypoxia had been studied. Prior to study experimental animals have been divided into two groups depending on resistance to hypobaric hypoxia. In brain mitochondria of high-resistant to hypoxia rats increase of the nitrites-ions contents and also intensification of pro- and antioxidative processes were registered in comparison with the control group. Decrease of all investgated free radical homeostasis parameters in brain mitochondria of low-resistant to hypoxia animals in comparison with the control group was determined. Administration of pro-hypoxic factor in toxic dose allowed us to reveal specific peculiarities of redox processes development in the brain mitochondria of experimental animals with different resistance to hypoxia.
研究了在缺氧高峰期给予亚硝酸钠条件下大鼠脑线粒体的自由基稳态参数。在研究之前，根据对低压缺氧的耐受性，将实验动物分为两组。与对照组相比，在对缺氧具有高耐受性的大鼠的脑线粒体中，亚硝酸根离子含量增加，同时促氧化和抗氧化过程增强。与对照组相比，确定了对缺氧耐受性低的动物的脑线粒体中所有研究的自由基稳态参数均降低。给予中毒剂量的促缺氧因子使我们能够揭示对缺氧具有不同耐受性的实验动物脑线粒体中氧化还原过程发展的特定特征。
