浅表角膜切除术联合局部应用丝裂霉素C治疗犬角膜鳞状细胞癌

Superficial keratectomy and topical mitomycin C as therapy for a corneal squamous cell carcinoma in a dog.

作者信息

Karasawa K, Matsuda H, Tanaka A

机构信息

Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Graduate School, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.

出版信息

J Small Anim Pract. 2008 Apr;49(4):208-10. doi: 10.1111/j.1748-5827.2007.00402.x. Epub 2007 Aug 23.

DOI:10.1111/j.1748-5827.2007.00402.x

PMID:17725585

Abstract

A 10-year-old female West Highland white terrier was presented with refractory hyperplastic keratitis of the left cornea of one month's duration. At this time, a vascularised and rough lesion 5 mm in diameter was observed on the left cornea. No other abnormality was recognised on the affected eye. The corneal neoplasm was surgically removed and histologically diagnosed as a squamous cell carcinoma. For two months after the surgery, 0.04 percent mitomycin C (MMC) eye drops were applied as adjuvant chemotherapy. Primary corneal squamous cell carcinoma with no history of keratoconjunctivitis sicca is rare in dogs. In the present report, surgical removal of the neoplasm was combined with the topical administration of the anticancer drug mitomycin C and a good prognosis was obtained. The result indicates that the combination treatment used in this case may be an appropriate therapeutic choice for corneal squamous cell carcinoma in dogs.

摘要

一只10岁雌性西高地白梗犬因左眼顽固性增生性角膜炎就诊，病程1个月。此时，在左眼角膜上观察到一个直径5毫米的血管化且粗糙的病变。患眼未发现其他异常。通过手术切除角膜肿瘤，组织学诊断为鳞状细胞癌。术后两个月，应用0.04%丝裂霉素C（MMC）滴眼液作为辅助化疗。在犬类中，无干燥性角结膜炎病史的原发性角膜鳞状细胞癌较为罕见。在本报告中，手术切除肿瘤并联合局部应用抗癌药物丝裂霉素C，获得了良好的预后。结果表明，该病例所采用的联合治疗可能是犬角膜鳞状细胞癌的一种合适治疗选择。