Ciancarelli I, Tozzi-Ciancarelli M G, Spacca G, Di Massimo C, Carolei A
Department of Neurology and Laboratory of Applied Physiology, University of L'Aquila, Piazzale Salvatore Tommasi 1, 67010 L'Aquila, Italy.
Cephalalgia. 2007 Oct;27(10):1136-41. doi: 10.1111/j.1468-2982.2007.01398.x. Epub 2007 Aug 24.
Chronic migraine (1.5.1) is burdened with headache-related disability. During noxious stimulation, changes of cerebral blood flow enhance the release of oxygen free radicals that react with nitric oxide (NO). We investigated the role of biofeedback in limiting migraine disability by influencing oxidative stress. Peroxides, NO and superoxide dismutase (SOD) were analysed in 20 female subjects with chronic migraine and in 20 female healthy controls before and after biofeedback sessions. NO(x) levels (23.7 +/- 4.2 vs. 34.9 +/- 4.6 microm; P < 0.05) and SOD activity (6.5 +/- 1.0 vs. 8.0 +/- 0.7 U/ml; P < 0.05) were lower in migraine sufferers before treatment than in healthy controls, whereas peroxide levels (145.8 +/- 40.3 vs. 78.0 +/- 20.0 microm; P < 0.05) were higher in migraine sufferers before treatment than in healthy controls. In migraine sufferers NO(x) levels (23.7 +/- 4.2 vs. 31.3 +/- 7.1 microm; P < 0.05) and SOD activity (6.5 +/- 1.0 vs. 7.9 +/- 0.9 U/ml; P < 0.05) were lower before than after treatment, whereas peroxide levels (145.8 +/- 40.3 vs. 82.4 +/- 21.1 microm; P < 0.05) were higher before than after treatment. SOD serum activity correlated positively with NO(x) serum levels and negatively with peroxide serum levels in healthy controls and in chronic migraine sufferers before and after biofeedback. The mean Migraine Disability Assessment Score before biofeedback sessions was higher than after treatment (36.9 +/- 13.9 vs. 18.8 +/- 10.4; P < 0.001). The effectiveness of biofeedback in limiting chronic migraine may be related to muscular relaxation associated with decreased oxidative stress accompanied by psychological well-being.
慢性偏头痛（1.5.1）伴有与头痛相关的功能障碍。在有害刺激期间，脑血流的变化会增强与一氧化氮（NO）发生反应的氧自由基的释放。我们研究了生物反馈通过影响氧化应激在限制偏头痛功能障碍方面的作用。在生物反馈治疗前后，对20名患有慢性偏头痛的女性受试者和20名健康女性对照者的过氧化物、NO和超氧化物歧化酶（SOD）进行了分析。偏头痛患者治疗前的NO(x)水平（23.7±4.2对34.9±4.6微摩尔；P<0.05）和SOD活性（6.5±1.0对8.0±0.7 U/ml；P<0.05）低于健康对照者，而偏头痛患者治疗前的过氧化物水平（145.8±40.3对78.0±20.0微摩尔；P<0.05）高于健康对照者。在偏头痛患者中，治疗前的NO(x)水平（23.7±4.2对31.3±7.1微摩尔；P<0.05）和SOD活性（6.5±1.0对7.9±0.9 U/ml；P<0.05）低于治疗后，而过氧化物水平（145.8±40.3对82.4±21.1微摩尔；P<0.05）治疗前高于治疗后。在健康对照者以及生物反馈治疗前后的慢性偏头痛患者中，SOD血清活性与NO(x)血清水平呈正相关，与过氧化物血清水平呈负相关。生物反馈治疗前的平均偏头痛功能障碍评估得分高于治疗后（36.9±13.9对18.8±10.4；P<0.001）。生物反馈在限制慢性偏头痛方面的有效性可能与肌肉放松有关，这种放松伴随着氧化应激的降低以及心理幸福感。
