Selek Salih, Savas Haluk A, Gergerlioglu H Serdar, Bulbul Feridun, Uz Efkan, Yumru Mehmet
Department of Psychiatry, Sahinbey Research Hospital, Medical Faculty of Gaziantep University, Turkey.
J Affect Disord. 2008 Apr;107(1-3):89-94. doi: 10.1016/j.jad.2007.08.006. Epub 2007 Sep 14.
Studies have already pointed out a possible pathophysiological role of oxidative and antioxidative molecules in bipolar disorder. We aimed to evaluate the activity and levels of antioxidant superoxide dismutase (SOD), and oxidant nitric oxide (NO), in bipolar I depressive episode (BD-DE) patients in a prospective design.
30 BD-DE patients, diagnosed according to DSM IV, and 30 healthy volunteer controls were included. The serum levels of NO and SOD have been studied when admitted to hospital (1st) and on the 30th days. Clinical outcome was measured by Hamilton Depression Scale (HAM-D). The patients were allowed to have their treatments. One patient was dropped out due to insufficient sampling.
As in the previous studies, NO 1st day levels were significantly higher in patients and SOD 1st day activity was significantly low (p<0.01). NO levels significantly decreased (p<0.01) and normalized, as SOD activity significantly increased but did not reach to the controls' levels (p<0.01) on the 30th day.
Despite normalized NO levels, persistent low SOD activity might point out an oxidative imbalance in BD-DE. Chronic low SOD activity may be associated with incapacity of coping with oxidative stress. This research connotes the probable oxidative imbalance in BD-DE and discusses that phenomenon within the continuum of the disease state.
研究已指出氧化和抗氧化分子在双相情感障碍中可能的病理生理作用。我们旨在以前瞻性设计评估双相I型抑郁发作（BD-DE）患者抗氧化超氧化物歧化酶（SOD）的活性和水平以及氧化剂一氧化氮（NO）的水平。
纳入30例根据DSM-IV诊断的BD-DE患者和30名健康志愿者作为对照。在入院时（第1天）和第30天时研究血清NO和SOD水平。通过汉密尔顿抑郁量表（HAM-D）测量临床结局。允许患者接受治疗。1例患者因样本不足退出研究。
与先前研究一样，患者第1天的NO水平显著更高，第1天的SOD活性显著更低（p<0.01）。第30天时，NO水平显著降低（p<0.01）并恢复正常，而SOD活性显著增加，但未达到对照组水平（p<0.01）。
尽管NO水平恢复正常，但持续的低SOD活性可能表明BD-DE存在氧化失衡。慢性低SOD活性可能与应对氧化应激的能力不足有关。本研究表明BD-DE可能存在氧化失衡，并在疾病状态的连续过程中讨论了该现象。
