Departmant of Neurology, Istanbul Başaksehir Cam ve Sakura City Hospital, Istanbul, Turkey.
Departmant of Neurology, Artvin State Hospital, Artvin, Turkey.
Medicine (Baltimore). 2023 Feb 3;102(5):e32810. doi: 10.1097/MD.0000000000032810.
Serum uric acid (SUA), the end product of purine metabolism acts as an antioxidant and is related to oxidative stress. It has been reported that SUA may be involved in the pathogenesis of neurodegenerative diseases including Alzheimer disease, Huntington disease, Parkinson disease, and multiple sclerosis. However, studies evaluating SUA levels in migraine are scarce. This study aimed to explore the relationship between pain characteristics and SUA levels in patients with migraine and compare SUA levels in migraine patients during a headache attack and headache-free period with those control groups. This prospective, cross-sectional study included 78 patients with migraine and 78 healthy subjects who were randomly selected from hospital personnel as the control group. Headache characteristics (duration of attack, pain intensity, and headache frequency) and sociodemographic features were recorded. The SUA level was measured once in the control group and twice in the migraine patients, during the migraine attack and headache-free periods. Although the SUA levels of the migraine group in the headache-free period were higher than those of the control group, the difference was not statistically significant. Gender was not significantly related to the change in SUA levels between the attack and headache-free period. When the correlation between age, duration of migraine, frequency, duration, and intensity of pain was evaluated; the difference between SUA levels in female migraine patients was weakly correlated with headache intensity, whereas male patients had a moderate correlation. ( P < .05; R > 0.250, and R > 0.516, respectively). The difference in SUA level in the migraine attack period compared to the headache-free period showing a positive correlation with pain intensity suggested that SUA may have a role in migraine due to its antioxidant role.
血清尿酸（SUA）是嘌呤代谢的终产物，具有抗氧化作用，与氧化应激有关。有报道称，SUA 可能与包括阿尔茨海默病、亨廷顿病、帕金森病和多发性硬化症在内的神经退行性疾病的发病机制有关。然而，评估偏头痛患者 SUA 水平的研究较少。本研究旨在探讨偏头痛患者疼痛特征与 SUA 水平之间的关系，并比较偏头痛发作期和无头痛期 SUA 水平与对照组之间的差异。这是一项前瞻性、横断面研究，纳入了 78 名偏头痛患者和 78 名随机选自医院工作人员的健康对照者。记录头痛特征（发作持续时间、疼痛强度和头痛频率）和社会人口学特征。在对照组中，SUA 水平仅测量 1 次，而在偏头痛患者中，在偏头痛发作期和无头痛期各测量 2 次。尽管偏头痛组在无头痛期的 SUA 水平高于对照组，但差异无统计学意义。性别与发作期和无头痛期 SUA 水平变化无显著相关性。评估年龄、偏头痛持续时间、频率、疼痛持续时间和强度之间的相关性时；女性偏头痛患者的 SUA 水平差异与头痛强度呈弱相关，而男性患者呈中度相关。（P<0.05；R>0.250 和 R>0.516，分别）。偏头痛发作期与无头痛期 SUA 水平的差异与疼痛强度呈正相关，这表明 SUA 可能因其抗氧化作用而在偏头痛中发挥作用。
