Gay Cyril G, Richie Thomas L, Pastoret Paul-Pierre, Minguez-Tudela Isabel, de Baetselier Patrick, Göbel Thomas, Goddeeris Bruno, Kaiser Pete, Morrison Ivan, Sánchez-Vizcaíno José Manuel, Anderson Kevin, Baillie Leslie W, Brown Wendy C, Estes D Mark, Herrera Eileen, Nara Peter L, Ockenhouse Chris F, Roth James A, Sztein Marcelo B
Animal Production and Protection, Agriculture Research Service, United States Department of Agriculture, 5601 Sunnyside Avenue, Beltsville, MD 20705, United States.
Vaccine. 2007 Oct 10;25(41):7007-11. doi: 10.1016/j.vaccine.2007.06.068. Epub 2007 Aug 6.
As the 21st century unfolds, infectious diseases remain one of the most significant threats to our economy, our food animal production systems, animal welfare, and most importantly, the lives of people worldwide, regardless of their economic standing. The potential use of biological threat agents for terrorism or biowarfare further undermines the security of our society. Arguably, vaccines represent the single most cost-effective, medically delivered strategy for confronting these challenges. The workshop "Advances in Immunology and Vaccine Discovery" was organized to address these challenges, based on the conviction that the interface between immunology and vaccinology offers the best prospects for major breakthroughs in vaccine discovery and development. Six focus areas were identified by workshop organizers: (1) pathogen immune evasion; (2) innate immunity; (3) mucosal immunity; (4) immunogenetics; (5) comparative immunology; and (6) genomics. These areas provided opportunities to elucidate how protective immunity may relate to the disruption of the molecular mechanisms that underlie host-pathogen interactions. A report generated by workshop organizers and participants provides key recommendations and identifies important research gaps, needs, future steps, and potential strategic US-EU collaborations. The report is available on line through ScienceDirect (URL).
随着21世纪的展开，传染病仍然是对我们的经济、食用动物生产系统、动物福利，以及最重要的是，对世界各地人们的生命构成的最重大威胁之一，无论他们的经济状况如何。生物威胁制剂被用于恐怖主义或生物战的可能性进一步破坏了我们社会的安全。可以说，疫苗是应对这些挑战的最具成本效益的医学策略。“免疫学与疫苗发现进展”研讨会的举办旨在应对这些挑战，其依据的信念是，免疫学与疫苗学的交叉领域为疫苗发现和开发取得重大突破提供了最佳前景。研讨会组织者确定了六个重点领域：（1）病原体免疫逃逸；（2）固有免疫；（3）黏膜免疫；（4）免疫遗传学；（5）比较免疫学；（6）基因组学。这些领域提供了阐明保护性免疫如何与宿主-病原体相互作用背后的分子机制破坏相关的机会。研讨会组织者和参与者生成的一份报告提供了关键建议，并确定了重要的研究差距、需求、未来步骤以及美欧潜在的战略合作。该报告可通过ScienceDirect在线获取（网址）。
