Division of Infectious Diseases, Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, Canada.
Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
Trends Immunol. 2016 Aug;37(8):523-534. doi: 10.1016/j.it.2016.05.005. Epub 2016 Jun 22.
Infectious diseases remain a major cause of death in infancy. Vaccination is a proven-effective strategy to reduce the risk of infectious diseases. However, important gaps remain in our understanding of vaccine responses in early life. Systems vaccinology has provided new insight into mechanisms and predictors of vaccine responses. However, systems vaccinology has not yet been systematically applied to infants younger than 12 months of age. Here, we review the knowledge gained from systems vaccinology studies of vaccines that are licensed for administration to infants. We propose that systems vaccinology should be applied to age-specific studies focused on protection, to derive the necessary insight for optimal design of vaccines for the very young.
传染病仍然是婴儿死亡的主要原因。接种疫苗是降低传染病风险的有效策略。然而，我们对于婴儿期疫苗反应的理解仍存在重要空白。系统疫苗学为疫苗反应的机制和预测因素提供了新的见解。然而，系统疫苗学尚未系统地应用于 12 个月以下的婴儿。在这里，我们回顾了从已获许可用于婴儿接种的疫苗的系统疫苗学研究中获得的知识。我们建议将系统疫苗学应用于针对保护作用的特定年龄研究，为设计针对非常年幼婴儿的疫苗提供必要的见解。
