卡介苗对麻风病的持久保护作用。
Long lasting BCG protection against leprosy.
作者信息
Rodrigues Laura Cunha, Kerr-Pontes Ligia Regina Sansigolo, Frietas Max Victor Carioca, Barreto Maurício Lima
机构信息
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK.
出版信息
Vaccine. 2007 Sep 28;25(39-40):6842-4. doi: 10.1016/j.vaccine.2007.07.032. Epub 2007 Aug 6.
BACKGROUND
BCG vaccine protects against leprosy.
OBJECTIVES
Estimate BCG protection against leprosy by age by age.
METHODS
A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.
RESULTS
BCG protection against leprosy was 86% (95% CI: 77-92%) in the age group 18-29; 54% (95% CI: -37% to 85%) in the age group 30-39 and 32% (95% CI: -3% to 56%) in those aged 40 or more.
CONCLUSIONS
BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.
背景
卡介苗可预防麻风病。
目的
按年龄估算卡介苗对麻风病的预防效果。
方法
一项病例对照研究，有226例麻风病患者和857名对照。通过检查卡介苗疤痕确定卡介苗接种情况。给出了三个年龄组的预防效果。
结果
18 - 29岁年龄组中，卡介苗对麻风病的预防效果为86%（95%可信区间：77 - 92%）；30 - 39岁年龄组为54%（95%可信区间：-37%至85%），40岁及以上年龄组为32%（95%可信区间：-3%至56%）。
结论
卡介苗预防麻风病的效力很可能持续三十年，甚至可能更长。卡介苗接种肯定有助于全球麻风病发病率的降低。
Zotero 插件