Asklund C, Jørgensen N, Skakkebaek N E, Jensen T K
University Department of Growth and Reproduction, University Hospital of Copenhagen, GR-5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Hum Reprod. 2007 Oct;22(10):2639-46. doi: 10.1093/humrep/dem217. Epub 2007 Aug 29.
Some studies have suggested an association between paternal subfertility and hypospadias among their sons, although the association has not been systematically investigated. We therefore compared male reproductive health among a group of fathers of boys with hypospadias and a group of fathers to normal children.
A total of 64 fathers of boys with hypospadias participated; 349 partners of pregnant women served as a control group. All men delivered a semen sample, had a blood sample drawn, underwent a physical examination and completed a questionnaire.
Fathers of boys with hypospadias had a significantly lower median sperm concentration (54.1 x 10(6)/ml) (P = 0.004) and total sperm count (222.0 x 10(6)) (P = 0.009) than the controls (81.2 and 326.0 x 10(6)/ml). In addition, the fathers of boys with hypospadias more often reported to have had disorders in the urogenital system (hypospadias, cryptorchidism and testicular cancer) (11/64) (P < 0.001) than the control group (16/349). No significant differences in waiting time to pregnancy was observed, however, 15% of fathers to boys with hypospadias had received fertility treatment.
Fathers of boys with hypospadias not only have an increased frequency of hypospadias, but also decreased semen quality. Most likely fathers and sons share the same susceptibility genes for reproductive dysfunction, but additional impact of environmental factors cannot be excluded.
一些研究表明父亲生育力低下与其儿子患尿道下裂之间存在关联，尽管这种关联尚未得到系统研究。因此，我们比较了一组尿道下裂男孩的父亲与一组正常儿童父亲的男性生殖健康状况。
共有64名尿道下裂男孩的父亲参与；349名孕妇的伴侣作为对照组。所有男性均提供精液样本、采集血样、接受体格检查并完成一份问卷。
尿道下裂男孩的父亲的精子浓度中位数（54.1×10⁶/ml）（P = 0.004）和总精子数（222.0×10⁶）（P = 0.009）显著低于对照组（分别为81.2和326.0×10⁶/ml）。此外，尿道下裂男孩的父亲报告患有泌尿生殖系统疾病（尿道下裂、隐睾症和睾丸癌）的比例（11/64）（P < 0.001）高于对照组（16/349）。然而，两组在怀孕等待时间上未观察到显著差异，不过，15%的尿道下裂男孩的父亲接受过生育治疗。
尿道下裂男孩的父亲不仅尿道下裂的发生率增加，精液质量也有所下降。父子很可能共享相同的生殖功能障碍易感基因，但不能排除环境因素的额外影响。
